Results 61 to 70 of about 8,269,931 (302)

iCLIP predicts the dual splicing effects of TIA-RNA interactions [PDF]

, 2010
The regulation of alternative splicing involves interactions between RNA-binding proteins and pre-mRNA positions close to the splice sites. T-cell intracellular antigen 1 (TIA1) and TIA1-like 1 (TIAL1) locally enhance exon inclusion by recruiting U1 ...
Nicholas M. Luscombe, Wang, Zheng, Zarnack, Kathi, Jernej Ule, Kayikci Melis, Rot, Gregor, Curk, Tomaz, Ule, Jernej, Zhen Wang, Luscombe, Nicholas M, Kathi Zarnack, Briese Michael, Zupan Blaž, Michael Briese, Melis Kayikci, Blaž Zupan, Ule Jernej, Wang Zhen, Zupan, Blaz, Zarnack Kathi, Luscombe Nicholas M., Briese, Michael, Curk Tomaž, Nicholas M Luscombe, Gregor Rot, Rot Gregor, Tomaž Curk, Kayikci, Melis   +27 more
core   +2 more sources

Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3 [PDF]

, 2009
The CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-like factors (CELF) family or the Bruno-like family and is involved in the control of splicing, translation and mRNA degradation.
Kanako Kuwasako, Naohiro Kobayashi, Shirouzu, Mikako, Mari Takahashi, Yutaka Muto, Takahashi, Mari, Someya, Tatsuhiko, Takanori Kigawa, Kengo Tsuda, Kuwasako, Kanako, Kobayashi, Naohiro, Peter Güntert, Mikako Shirouzu, Muto, Yutaka, Sugano, Sumio, Akiko Tanaka, Tatsuhiko Someya, Makoto Inoue, Sumio Sugano, Terada, Takaho, Inoue, Makoto, Kigawa, Takanori, Yokoyama, Shigeyuki, Tsuda, Kengo, Takaho Terada, Shigeyuki Yokoyama, Tanaka, Akiko, Güntert, Peter   +27 more
core   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

SpliceAid-F: a database of human splicing factors and their RNA-binding sites [PDF]

Nucleic Acids Research, 2012
A comprehensive knowledge of all the factors involved in splicing, both proteins and RNAs, and of their interaction network is crucial for reaching a better understanding of this process and its functions. A large part of relevant information is buried in the literature or collected in various different databases.
Matteo Giulietti, Francesco Piva, Mattia D'Antonio, Paolo D'Onorio De Meo, Daniele Paoletti, Tiziana Castrignanò, Anna Maria D'Erchia, Ernesto Picardi, Federico Zambelli, Giovanni Principato, Giulio Pavesi, Graziano Pesole   +11 more
openaire   +4 more sources

RNA modification-mediated aberrant alternative splicing: An underlying driver of disease pathogenesis

Cell Investigation
RNA modification and alternative splicing are central mechanisms in the regulation of eukaryotic gene expression. RNA modifications, which occur in a variety of chemical forms, exert widespread influences on RNA structure, stability and function ...
Jin Zeng, Li-Ting Diao, Shu-Juan Xie, Zhen-Dong Xiao   +3 more
doaj   +1 more source

Domain orientation in the RNA helicase YxiN and the role of conformational changes for RNA unwinding [PDF]

, 2010
The RNA helicase YxiN from Bacillus subtilis is a member of the family of DEAD box proteins. YxiN is able to unwind RNA double strands in an ATP-dependent manner. The ability to catalyse RNA rearrangement is in vivo presumably necessary for the bacterial
Karow, Anne R.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The potential impact of RNA splicing abnormalities on immune regulation in endometrial cancer

Cell Death and Disease
RNA splicing controls the post-transcriptional level of gene expression, allowing for the synthesis of many transcripts with various configurations and roles.
Minyue Cao, Jiayu Yan, Yan Ding, Yiqin Zhang, Yihan Sun, Genyi Jiang, Yanli Zhang, Bilan Li   +7 more
doaj   +1 more source

hnRNP A1 in RNA metabolism regulation and as a potential therapeutic target

Frontiers in Pharmacology, 2022
Abnormal RNA metabolism, regulated by various RNA binding proteins, can have functional consequences for multiple diseases. Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an important RNA binding protein, that regulates various RNA metabolic ...
Jianguo Feng, Jianguo Feng, Jianguo Feng, Jianlong Zhou, Jianlong Zhou, Yunxiao Lin, Wenhua Huang, Wenhua Huang   +7 more
doaj   +1 more source

Splicing therapeutics in SMN2 and APOB [PDF]

, 2009
Splicing therapeutics are defined as the deliberate modification of RNA splicing to achieve therapeutic goals. Various techniques for splicing therapeutics have been described, and most of these involve the use of antisense oligonucleotide-based ...
Krainer, AR, Khoo, B., Krainer, A. R., Khoo, B   +3 more
core