Results 201 to 210 of about 522,625 (254)

MagPiezo: A Magnetogenetic Platform for Remote Activation of Endogenous Piezo1 Channels in Endothelial Cells

open access: yesAdvanced Functional Materials, EarlyView.
MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández   +7 more
wiley   +1 more source
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The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability

Biochemistry, 2022
We examined the complex network of interactions among RNA, the metabolome, and divalent Mg2+ under conditions that mimic the Escherichia coli cytoplasm. We determined Mg2+ binding constants for the top 15 E. coli metabolites, comprising 80% of the metabolome by concentration at physiological pH and monovalent ion concentrations. These data were used to
Jacob P. Sieg   +4 more
openaire   +2 more sources

Control of RNA Stability in Immunity

Annual Review of Immunology, 2021
Posttranscriptional control of mRNA regulates various biological processes, including inflammatory and immune responses. RNA-binding proteins (RBPs) bind cis-regulatory elements in the 3′ untranslated regions (UTRs) of mRNA and regulate mRNA turnover and translation.
Shizuo, Akira, Kazuhiko, Maeda
openaire   +2 more sources

Thermodynamic Studies of RNA Stability

Journal of Biomolecular Structure and Dynamics, 1984
Enthalpies and entropies of helix stabilization due to addition of 3' terminal unpaired nucleotides to a CCGG or GGCC core double helix are derived from UV melting studies. The results suggest stacking provides a significant fraction of the free energy of a terminal base pair.
S M, Freier   +3 more
openaire   +2 more sources

RNA stabilization in hyperthermophilic archaea

Annals of the New York Academy of Sciences, 2019
AbstractAnalyses of the RNA metabolism of hyperthermophilic archaea highlight the efficiency of regulatory RNAs and RNA‐guided processes at extreme temperatures. These organisms must overcome the intrinsic thermolability of RNAs. Elevated levels of RNA modifications and structured GC‐rich regions are observed for many universal noncoding RNA families ...
Gomes-Filho, J., Randau, L.
openaire   +3 more sources

Chloroplast RNA processing and stability

Photosynthesis Research, 2004
Primary chloroplast transcripts are processed in a number of ways, including intron splicing, internal cleavage of polycistronic RNAs, and endonucleolytic or exonucleolytic cleavages at the transcript termini. All chloroplast RNAs are also subject to degradation, although a curious feature of many chloroplast mRNAs is their relative longevity.
David L, Herrin, Jöerg, Nickelsen
openaire   +2 more sources

Regulation of RNA Stability Through RNA Modification

2021
As intracellular RNA levels are determined by the balance between RNA synthesis and decay, RNA stability is a critical factor in the quantity of intracellular RNA. Recent advances in epitranscriptomic measuring techniques have shown that RNA modifications, such as methylation and acetylation, affect RNA stability, including those of messenger RNA (mRNA)
Kentaro Kawata, Nobuyoshi Akimitsu
openaire   +1 more source

RNA Structure and Stability

Seminars in Virology, 1997
Abstract RNA molecules fold into specific base-paired conformations that contain single-stranded regions, A-form double helices, hairpin loops, internal loops, bulges, junctions, pseudoknots, kissing hairpins, and so forth. These structural motifs are recognized by proteins, other RNAs, and other parts of the same RNA.
Jacek Nowakowski, Ignacio Tinoco
openaire   +1 more source

Gene expression regulated by RNA stability

Science, 2020
The factor responsible for autoregulation of tubulin RNA stability is ...
Ofer, Shoshani, Don W, Cleveland
openaire   +2 more sources

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