Results 201 to 210 of about 544,829 (251)

Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

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Control of RNA Stability in Immunity

Annual Review of Immunology, 2021
Posttranscriptional control of mRNA regulates various biological processes, including inflammatory and immune responses. RNA-binding proteins (RBPs) bind cis-regulatory elements in the 3′ untranslated regions (UTRs) of mRNA and regulate mRNA turnover and translation.
Shizuo Akira, Kazuhiko Maeda
exaly   +3 more sources

Modelling molecular stability in the RNA world

Computational Biology and Chemistry, 2005
RNA secondary structure, stability and melting curves are calculated for a model of a possible ribozyme corresponding to the RNA directed RNA polymerase (ribopolymerase) required in the RNA world. From these calculations, rates of folding and hybridisation are estimated and used in a stochastic simulation of the dynamics of a population of ...
William R Taylor
exaly   +3 more sources

The Metabolome Weakens RNA Thermodynamic Stability and Strengthens RNA Chemical Stability

Biochemistry, 2022
We examined the complex network of interactions among RNA, the metabolome, and divalent Mg2+ under conditions that mimic the Escherichia coli cytoplasm. We determined Mg2+ binding constants for the top 15 E. coli metabolites, comprising 80% of the metabolome by concentration at physiological pH and monovalent ion concentrations. These data were used to
Jacob P. Sieg, Lauren N. McKinley, Melanie J. Huot, Neela H. Yennawar, Philip C. Bevilacqua   +4 more
openaire   +2 more sources

Stabilizing RNA by the Sonochemical Formation of RNA Nanospheres

Small, 2011
AbstractBiological macromolecules, including DNA, RNA, and proteins, have intrinsic features that make them potential building blocks for the bottom‐up fabrication of nanodevices. Unlike DNA, RNA is a more versatile molecule whose range in the cell is from 21 to thousands of nucleotides and is usually folded into stem and loop structures. RNA is unique
Ulyana, Shimanovich, Vadim, Volkov, Dror, Eliaz, Adva, Aizer, Shulamit, Michaeli, Aharon, Gedanken   +5 more
openaire   +2 more sources

Polyamines, ribonucleases, and the stability of RNA

Molecular and Cellular Biochemistry, 1977
The polyamines influence the activity of many enzymes involved in the synthesis and degradation of RNA. These organic cations (putrescine, spermidine, spermine) stimulate, for example, many DNA-dependent RNA polymerases and affect both RNA chain elongation and initiation.
T P, Karpetsky, P A, Hieter, J J, Frank, C C, Levy   +3 more
openaire   +2 more sources

RNA stabilization in hyperthermophilic archaea

Annals of the New York Academy of Sciences, 2019
AbstractAnalyses of the RNA metabolism of hyperthermophilic archaea highlight the efficiency of regulatory RNAs and RNA‐guided processes at extreme temperatures. These organisms must overcome the intrinsic thermolability of RNAs. Elevated levels of RNA modifications and structured GC‐rich regions are observed for many universal noncoding RNA families ...
Gomes-Filho, J., Randau, L.
openaire   +3 more sources