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Solution Structure Probing of RNA Structures
2008Single-stranded RNA plant viruses not only code for viral proteins within their RNA genomes, they often maintain elaborate RNA secondary structures. These structures can be integral to a variety of viral processes, such as viral translation, genome replication, subgenomic mRNA transcription, and genome encapsidation.
Marc R, Fabian, K Andrew, White
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2011
The prediction of RNA structure can be a first important step for the functional characterization of novel ncRNAs. Especially for the very meaningful secondary structure, there is a multitude of computational prediction tools. They differ not only in algorithmic details and the underlying models but also in what exactly they are trying to predict. This
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The prediction of RNA structure can be a first important step for the functional characterization of novel ncRNAs. Especially for the very meaningful secondary structure, there is a multitude of computational prediction tools. They differ not only in algorithmic details and the underlying models but also in what exactly they are trying to predict. This
openaire +2 more sources
On the Approximation of Optimal Structures for RNA-RNA Interaction
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2009The interaction of two RNA molecules is a common mechanism for many biological processes. Small interfering RNAs represent a simple example of such an interaction. But other more elaborate instances of RNA-RNA interaction exist. Therefore, algorithms that predict the structure of the RNA complex thus formed are of great interest.
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2010
We give an overview of RNA structure predictions in this chapter. We discuss here the main approaches to RNA structure prediction: combinatorial approaches, comparative approaches, and kinetic approaches. The main algorithms and mathematical concepts such as transformational grammars will be briefly introduced.
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We give an overview of RNA structure predictions in this chapter. We discuss here the main approaches to RNA structure prediction: combinatorial approaches, comparative approaches, and kinetic approaches. The main algorithms and mathematical concepts such as transformational grammars will be briefly introduced.
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Structural Probing of RNA Thermosensors
2009Chemical probing of RNA structure has become one of the most popular approaches to map the conformation of RNA molecules of various sizes under well-defined experimental conditions. The method monitors the sensitivity of each nucleotide to various chemicals, which reflects its hydrogen-bonding environment within the RNA molecule.
Chiaruttini, C. +2 more
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1989
Considering the chemical similarity between DNA and RNA, one can only wonder at the different functions RNA performs. This is certainly due to its ability to adopt complex tertiary structures. Apart from a genomic role in some viruses, RNA is mostly involved in the machinery that expresses the genetic information from DNA to proteins.
Delarue, M., Moras, Dino
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Considering the chemical similarity between DNA and RNA, one can only wonder at the different functions RNA performs. This is certainly due to its ability to adopt complex tertiary structures. Apart from a genomic role in some viruses, RNA is mostly involved in the machinery that expresses the genetic information from DNA to proteins.
Delarue, M., Moras, Dino
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1995
Abstract Our understanding of RNA’s central role in many cellular functions has increased dramatically since the discovery of RNA enzymatic activity (1). The field of structural biology has also made tremendous advances in the last decade and X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy have provided three ...
Gabriele V Arani, Arthur Pardi
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Abstract Our understanding of RNA’s central role in many cellular functions has increased dramatically since the discovery of RNA enzymatic activity (1). The field of structural biology has also made tremendous advances in the last decade and X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy have provided three ...
Gabriele V Arani, Arthur Pardi
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Modulation of Noncoding RNAs (ncRNAs) and Their Potential Role as Therapeutics
Medical Epigenetics, 2021Luciano Pirola +2 more
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Targeting RNA Structures With Small Molecules
Nature Reviews Drug Discovery, 2022Quentin Gibaut +2 more
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