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RNA Tertiary Structure Mediation by Adenosine Platforms
Science, 1996The crystal structure of a group I intron domain reveals an unexpected motif that mediates both intra- and intermolecular interactions. At three separate locations in the 160-nucleotide domain, adjacent adenosines in the sequence lie side-by-side and form a pseudo-base pair within a helix.
J. Cate +8 more
semanticscholar +3 more sources
A compact RNA tertiary structure contains a buried backbone-K+ complex.
Journal of Molecular Biology, 2002G. Conn +4 more
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Tertiary Motifs in RNA Structure and Folding
Angewandte Chemie - International Edition, 1999Specific tertiary structural motifs determine the complete architecture of RNA molecules (see picture for examples). Within the last few years a number of high-resolution crystal structures of complex RNAs have led to new insights into the mechanisms by which these complex folds are attained.
Jennifer Doudna, Robert T Batey
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Mining RNA Tertiary Motifs With Structure Graphs [PDF]
International Conference on Scientific and Statistical Database Management: [proceedings] International Conference on Scientific and Statistical Database Management, 2007 We present a novel application of graph database mining to identify tertiary motifs in RNA structures. In our method, we abstract an RNA molecule as a labeled graph and use a frequent subgraph mining technique to derive tertiary motifs. By applying our technique to ribosome RNA and transfer RNA, we have identified known RNA tertiary motifs such as the ...
Wei Wang, Jun Huan, Xueyi Wang
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Improvements of the Hierarchical Approach for Predicting RNA Tertiary Structure
Journal of Biomolecular Structure and Dynamics, 2011Computational prediction of RNA tertiary structures is a significant challenge, especially for longer RNA and pseudoknots. At present it is still difficult to do this by pure all-atom molecular dynamics simulation. One of possible approaches is through hierarchical steps: from sequence to secondary structure and then to tertiary structure.
Yunjie Zhao, Zhou Gong, Yi Xiao
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Pervasive Tertiary Structure in the Dengue Virus RNA Genome [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance RNA viruses usurp and reprogram host cells using short RNA genomes. RNA viruses encode the information required for their replication in both their primary sequences and higher-order structures formed when the RNA genome strand folds back on itself, but the extent of higher-order structure has remained unclear.
Jules B Weinstein +2 more
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Tertiary structure of ribosomal RNA
Current Opinion in Structural Biology, 1992Abstract The secondary structures of ribosomal RNAs have been deduced by comparative sequence analysis. The same approach has also suggested some higher-order tertiary interactions. Some of these are now being tested by direct experiment, and it is clear that tertiary interactions play an important functional role in stabilizing protein-binding sites
Thomas C. Gluick, David E. Draper
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Template-based prediction of RNA tertiary structure
2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2016RNA tertiary structure prediction approaches can be divided into two groups: de novo methods and template-based modeling. De novo are applicable only for small molecules while in case of medium and large size RNA molecules, template-based modeling needs to be employed.
Rastislav Galvanek +2 more
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