Results 71 to 80 of about 9,541,112 (326)
In vitro selection of RNAs with increased tertiary structure stability [PDF]
RNA, 1999 An in vitro selection system was devised to select RNAs based on their tertiary structural stability, independent of RNA activity. Selection studies were conducted on the P4-P6 domain from the Tetrahymena thermophila group I intron, an autonomous self-folding unit that contains several important tertiary folding motifs including the tetraloop receptor ...
K, Juneau, T R, Cech
openaire +2 more sources
Simultaneous prediction of RNA secondary structure and helix coaxial stacking
BMC Genomics, 2012 Background RNA secondary structure plays a scaffolding role for RNA tertiary conformation. Accurate secondary structure prediction can not only identify double-stranded helices and single stranded-loops but also help provide information for potential ...
Shareghi Pooya +3 more
doaj +1 more source
Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence [PDF]
, 2004 Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and ...
Evans, David J +6 more
core +1 more source
In silico optimization of RNA–protein interactions for CRISPR-Cas13-based antimicrobials
Biology Direct, 2022 RNA–protein interactions are crucial for diverse biological processes. In prokaryotes, RNA–protein interactions enable adaptive immunity through CRISPR-Cas systems.
Ho-min Park +7 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The structure of a rigorously conserved RNA element within the SARS virus genome.
PLoS Biology, 2005 We have solved the three-dimensional crystal structure of the stem-loop II motif (s2m) RNA element of the SARS virus genome to 2.7-A resolution. SARS and related coronaviruses and astroviruses all possess a motif at the 3' end of their RNA genomes ...
Michael P Robertson +5 more
doaj +1 more source
pknotsRG: RNA pseudoknot folding including near-optimal structures and sliding windows [PDF]
, 2007 Reeder J, Steffen P, Giegerich R. pknotsRG: RNA pseudoknot folding including near-optimal structures and sliding windows. NUCLEIC ACIDS RESEARCH. 2007;35(Web Server):W320-W324.RNA pseudoknots are an important structural feature of RNAs, but often ...
Reeder, Jens +2 more
core +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
RNA 3D structure prediction guided by independent folding of homologous sequences
BMC Bioinformatics, 2019 Background The understanding of the importance of RNA has dramatically changed over recent years. As in the case of proteins, the function of an RNA molecule is encoded in its tertiary structure, which in turn is determined by the molecule’s sequence ...
Marcin Magnus +3 more
doaj +1 more source
CSSR : assignment of secondary structure to coarse-grained RNA tertiary structures
Acta Crystallographica Section D Structural Biology, 2022 RNA secondary-structure (rSS) assignment is one of the most routine forms of analysis of RNA 3D structures. However, traditional rSS assignment programs require full-atomic structures of the individual RNA nucleotides. This prevents their application to the modeling of RNA structures in which base atoms are missing. To address this
Chengxin Zhang, Anna Marie Pyle
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