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RNA localization and transport [PDF]

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2018
RNA localization serves numerous purposes from controlling development and differentiation to supporting the physiological activities of cells and organisms. After a brief introduction into the history of the study of mRNA localization I will focus on animal systems, describing in which cellular compartments and in which cell types mRNA localization ...
Suter, Beat
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The nuclear connection in RNA transport and localization

Trends in Cell Biology, 2002
RNA-binding proteins are involved in various aspects of RNA metabolism such as processing, translational control, stabilization, localization and transport. Many of these proteins bind several RNA targets and have multiple functions. In this review we focus on RNA-binding proteins that are implicated in RNA transport and localization and that also have
Robert H Singer
exaly   +3 more sources

Transport of RNA between nucleus and cytoplasm

Seminars in Cell Biology, 1992
The transport out of the nucleus of RNAs transcribed by RNA polymerase II (U snRNAs and mRNAs) has not been extensively studied. Basic questions, such as whether export requires association of the RNA with specific proteins, are not yet definitively answered. Nevertheless, recent progress in this area has been significant.
Elisa Izaurralde, Iain W Mattaj, I W Mattaj   +2 more
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Nucleocytoplasmic transport of 5S ribosomal RNA

Seminars in Cell and Developmental Biology, 1997
Nucleocytoplasmic transport of 5S ribosomal RNA in Xenopus oocytes occurs in the context of small, non-ribosomal RNPs. The complex with the zinc finger protein TFIIIA (7S RNP) is exported from the nucleus and stored in the cytoplasm, whereas the complex with the ribosomal protein L5 (5S RNP) shuttles between the nucleus and the cytoplasm.
Tomáš Pieler
exaly   +3 more sources

RNA TRANSPORT

Annual Review of Neuroscience, 1997
▪ Abstract  RNA molecules synthesized in the nucleus are transported to their sites of function throughout the eukaryotic cell by specific transport pathways. This review focuses on transport of messenger RNA, small nuclear RNA, ribosomal RNA, and transfer RNA between the nucleus and the cytoplasm.
S, Nakielny, U, Fischer, W M, Michael, G, Dreyfuss   +3 more
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Nucleocytoplasmic RNA transport

Molecular and Cellular Biochemistry, 1985
A number of closely related post-transcriptional facets of RNA metabolism show nuclear compartmentation, including capping, methylation, splicing reactions, and packaging in ribonucleoprotein particles (RNP). These nuclear 'processing' events are followed by the translocation of the finished product across the nuclear envelope.
G A, Clawson, C M, Feldherr, E A, Smuckler   +2 more
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Axoplasmic transport of RNA

Journal of Neurobiology, 1973
AbstractThe transport of RNA from the ganglion cell bodies within the retina to the contralateral optic tectum has been studied in the chick following intraocular injection of radioactive uridine. By tracing the appearance of labeled RNA at the proximal end of the optic nerve as it leaves the eyeball and comparing this to the time of arrival of RNA ...
S C, Bondy, C J, Madsen
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Nucleocytoplasmic Transport of RNAs and RNA–Protein Complexes

Journal of Molecular Biology, 2016
RNAs and ribonucleoprotein complexes (RNPs) play key roles in mediating and regulating gene expression. In eukaryotes, most RNAs are transcribed, processed and assembled with proteins in the nucleus and then either function in the cytoplasm or also undergo a cytoplasmic phase in their biogenesis.
Katherine E, Sloan, Pierre-Emmanuel, Gleizes, Markus T, Bohnsack   +2 more
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Modulation of RNA transport by polyvinylpyrrolidone

Molecular Biology Reports, 1984
A number of studies have documented substantial loss of nuclear protein during aqueous nuclear isolation procedures. This loss can, to some extent, be counteracted by addition of impermeable macromolecules like polyvinylpyrrolidone, which prevent nuclear swelling.
G A, Clawson, J, Button, C H, Woo, E A, Smuckler   +3 more
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Systemic transport of RNA in plants

Trends in Plant Science, 2000
V.C. thanks Drs Yoon Rhee and Tzvi Tzfira for stimulating discussions and helpful comments. The work in our laboratories is supported by grants from National Insti-tutes of Health (GM50224 to V.C. and GM45224 to P.C.Z.), US Dept of Agriculture (94-02564), National Science Foundation (DBI-9975715) and US–Israel Binational Research and Development Fund ...
V, Citovsky, P, Zambryski
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