Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]
, 2007 Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas +15 more
core +1 more source
Extracellular vesicles mediate the horizontal transfer of an active LINE-1 retrotransposon
Journal of Extracellular Vesicles, 2019 Long interspersed element-1 (LINE-1 or L1) retrotransposons replicate through a copy-and-paste mechanism using an RNA intermediate. However, little is known about the physical transmission of retrotransposon RNA between cells.
Yumi Kawamura +4 more
doaj +1 more source
Cell Reports, 2019 Summary: Tightly regulated transport of messenger ribonucleoprotein (mRNP) granules to diverse locations of dendrites and axons is essential for appropriately timed protein synthesis within distinct sub-neuronal compartments.
Jen-Fei Chu +4 more
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How Structural Features Define Biogenesis and Function of Human Telomerase RNA Primary Transcript
Biomedicines, 2022 Telomerase RNA has been uncovered as a component of the telomerase enzyme, which acts as a reverse transcriptase and maintains the length of telomeres in proliferated eukaryotic cells.
Maria Rubtsova, Olga Dontsova
doaj +1 more source
Studies on the interaction between "Tobacco Mosaic Virus" movement protein and microtubules [PDF]
, 2003 During the invasion of a susceptible host, Tobacco mosaic virus (TMV) transports its RNA genome from sites of viral synthesis into neighbouring cells, thus potentiating the spread of infection.
Ashby, Jamie A.
core +1 more source
RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs
eLife, 2018 Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles (RNPs) and the regulation of their movement are poorly understood.
Mark A McClintock +6 more
doaj +1 more source
An active RNA transport mechanism into plant vacuoles. [PDF]
Nucleic Acids ResRNA degradation inside the plant vacuole by the ribonuclease RNS2 is essential for maintaining nucleotide concentrations and cellular homeostasis via the nucleotide salvage pathway. However, the mechanisms by which RNA is transported into the vacuole are
Floyd BE +10 more
europepmc +3 more sources
In vivo Imaging of oskar mRNA transport reveals the mechanism of posterior localization [PDF]
, 2008 oskar mRNA localization to the posterior of the Drosophila oocyte defines where the abdomen and germ cells form in the embryo. Although this localization requires microtubules and the plus end-directed motor, kinesin, its mechanism is controversial and ...
Zimyanin, Vitaly L +16 more
core +1 more source
Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40
Nature Communications, 2016 Roquin is an RNA-binding protein that prevents autoimmunity by limiting expression of receptors such as Ox40. Here, the authors identify an RNA structure that they describe as an alternative decay element, and they characterise its interaction with ...
Robert Janowski +12 more
doaj +1 more source
Identification of Novel Stress Granule Components That Are Involved in Nuclear Transport. [PDF]
PLoS ONE, 2013 BACKGROUND:Importin-α1 belongs to a subfamily of nuclear transport adaptors and participates in diverse cellular functions. Best understood for its role in protein transport, importin-α1 also contributes to other biological processes.
Hicham Mahboubi +3 more
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