Results 31 to 40 of about 3,158,683 (345)

Nucleosides for the treatment of respiratory RNA virus infections

Antiviral Chemistry & Chemotherapy, 2018
Influenza virus, respiratory syncytial virus, human metapneumovirus, parainfluenza virus, coronaviruses, and rhinoviruses are among the most common viruses causing mild seasonal colds.
Paul C Jordan, S. Stevens, J. Deval
semanticscholar   +1 more source

Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1

mBio, 2019
RNA-binding proteins (RBPs) control mRNA processing, stability, transport, editing, and translation. We recently conducted transcriptome analyses comparing normal (i.e., healthy) cervical tissue samples with human papillomavirus (HPV)-positive cervical ...
Junfen Xu, Habin Liu, Yanqin Yang, Xiaohong Wang, Poching Liu, Yang Li, Craig Meyers, Nilam Sanjib Banerjee, Hsu-Kun Wang, Maggie Cam, Weiguo Lu, Louise T. Chow, Xing Xie, Jun Zhu, Zhi-Ming Zheng   +14 more
doaj   +1 more source

Host Lipids in Positive-Strand RNA Virus Genome Replication

Frontiers in Microbiology, 2019
Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable ...
Zhenlu Zhang, Guijuan He, N. Filipowicz, G. Randall, G. Belov, B. G. Kopek, Xiaofeng Wang   +6 more
semanticscholar   +1 more source

RIG-I in RNA virus recognition

Virology, 2015
Antiviral immunity is initiated upon host recognition of viral products via non-self molecular patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition initiates signaling cascades that induce intracellular innate immune defenses and an inflammatory response that facilitates development of the acquired immune response.
Alison M Kell, M. Gale
semanticscholar   +4 more sources

Infection with the dengue RNA virus activates TLR9 signaling in human dendritic cells

EMBO Reports, 2018
Toll‐like receptors (TLRs) are important sensors that recognize pathogen‐associated molecular patterns. Generally, TLR9 is known to recognize bacterial or viral DNA but not viral RNA and initiate an immune response.
J. Lai, Mei-yi Wang, Chuan-Yueh Huang, Chien-Hsiang Wu, L. Hung, Chia-Ying Yang, Po-Yuan Ke, S. Luo, Shih-Jen Liu, Ling-Jun Ho   +9 more
semanticscholar   +1 more source

Alleviation of Postharvest Skin Dimpling of MN55 Apple Fruit and a Possible Association with Apple stem pitting virus

HortScience, 2021
MN55 is an apple (Malus ×domestica Borkh.) cultivar recently released by the University of Minnesota apple breeding program, with fruit marketed in the U.S. as Rave®. When stored for 4 months at 0 to 4 °C, MN55 fruit can develop several storage disorders,
Cindy B.S. Tong, Hsueh-Yuan Chang, James J. Luby, David Bedford, Benham E.L. Lockhart, Roy G. Kiambi, Dimitre Mollov   +6 more
doaj   +1 more source

Beclin1 restricts RNA virus infection in plants through suppression and degradation of the viral polymerase

Nature Communications, 2018
Autophagy emerges as an essential immunity defense against intracellular pathogens. Here we report that turnip mosaic virus (TuMV) infection activates autophagy in plants and that Beclin1 (ATG6), a core component of autophagy, inhibits virus replication.
Fangfang Li, Changwei Zhang, Yinzi Li, Guanwei Wu, X. Hou, Xue-ping Zhou, Aiming Wang   +6 more
semanticscholar   +1 more source

Virus against virus: a potential treatment for 2019-nCov (SARS-CoV-2) and other RNA viruses

Cell Research, 2020
The novel coronavirus, 2019-nCov (named as SARS-CoV-2 by ICTV Coronaviridae Study Group on February 12, 2020), causes severe respiratory illness and has been spreading around the world rapidly.
Tuan Minh Nguyen, Yang Zhang, P. Pandolfi   +2 more
semanticscholar   +1 more source

E6^E7, a Novel Splice Isoform Protein of Human Papillomavirus 16, Stabilizes Viral E6 and E7 Oncoproteins via HSP90 and GRP78

mBio, 2015
Transcripts of human papillomavirus 16 (HPV16) E6 and E7 oncogenes undergo alternative RNA splicing to produce multiple splice isoforms. However, the importance of these splice isoforms is poorly understood.
Masahiko Ajiro, Zhi-Ming Zheng
doaj   +1 more source

cGAS and STING: At the intersection of DNA and RNA virus-sensing networks

PLoS Pathogens, 2018
As the first line of host defense, the innate immune system utilizes germline-encoded receptors named pattern-recognition receptors (PRRs) to detect invading pathogens.
Guoxin Ni, Zhe Ma, B. Damania
semanticscholar   +1 more source