Results 41 to 50 of about 1,185,737 (360)

Lipids and RNA virus replication [PDF]

Current Opinion in Virology, 2014
Most viruses rely heavily on their host machinery to successfully replicate their genome and produce new virus particles. Recently, the interaction of positive-strand RNA viruses with the lipid biosynthetic and transport machinery has been the subject of intense investigation.
Kouacou V, Konan, Lorena, Sanchez-Felipe
openaire   +2 more sources

KSHV ORF57, a Protein of Many Faces

Viruses, 2015
Kaposi’s sarcoma-associated herpesvirus (KSHV) ORF57 protein (also known as mRNA transcript accumulation (Mta)) is a potent posttranscriptional regulator essential for the efficient expression of KSHV lytic genes and productive KSHV replication.
Vladimir Majerciak, Zhi-Ming Zheng
doaj   +1 more source

A petunia ethylene-responsive element binding factor, PhERF2, plays an important role in antiviral RNA silencing. [PDF]

, 2016
Virus-induced RNA silencing is involved in plant antiviral defense and requires key enzyme components, including RNA-dependent RNA polymerases (RDRs), Dicer-like RNase III enzymes (DCLs), and Argonaute proteins (AGOs).
Jiang, Cai-Zhong, Nandety, Raja Sekhar, Niu, Lixin, Reid, Michael S, Sun, Daoyang, Zhang, Yanlong   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Antagonistic activity against innate immunity determines virulence in mammalian bornaviruses

npj Viruses
Variegated squirrel bornavirus 1 (VSBV-1) is a lethal emerging disease that has been discovered in privately owned and zoo squirrels, but its pathogenicity as a zoonotic pathogen remains uncertain.
Akiko Makino, Chiaki Tanaka, Kan Fujino, Keizo Tomonaga   +3 more
doaj   +1 more source

Nanomolecular detection of human influenza virus type A using reverse transcription loop-mediated isothermal amplification assisted with rod-shaped gold nanoparticles [PDF]

, 2014
Reverse transcription loop-mediated isothermal amplification (RT-LAMP) and rod-shaped gold nanoparticles (gold nanorods; GNRs) were employed for nanomolecular detection of human influenza virus type A RNA.
Gill, P., Niazi, A., Nikbakht, H., Tabarraei, A.   +3 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Development of an RNA Virus-Based Episomal Vector Capable of Switching Transgene Expression

Frontiers in Microbiology, 2019
Viral vectors are efficient gene delivery systems, although most of these vectors still present limitations to their practical use, such as achieving only transient transgene expression and a risk of insertional mutations.
Yusuke Yamamoto, Yusuke Yamamoto, Keizo Tomonaga, Keizo Tomonaga, Keizo Tomonaga, Tomoyuki Honda   +5 more
doaj   +1 more source

Genome organization and interaction with capsid protein in a multipartite RNA virus. [PDF]

, 2020
We report the asymmetric reconstruction of the single-stranded RNA (ssRNA) content in one of the three otherwise identical virions of a multipartite RNA virus, brome mosaic virus (BMV).
Beren, Christian, Chakravarty, Antara, Cui, Yanxiang, Gelbart, William M, Knobler, Charles M, Rao, ALN, Yang, Xue, Zhou, Z Hong   +7 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source