Results 41 to 50 of about 3,158,683 (345)
Epistasis and the Adaptability of an RNA Virus [PDF]
Genetics, 2005 Abstract We have explored the patterns of fitness recovery in the vesicular stomatitis RNA virus. We show that, in our experimental setting, reversions to the wild-type genotype were rare and fitness recovery was at least partially driven by compensatory mutations.
Rafael Sanjuán +4 more
openaire +3 more sources
Development of an RNA Virus-Based Episomal Vector Capable of Switching Transgene Expression
Frontiers in Microbiology, 2019 Viral vectors are efficient gene delivery systems, although most of these vectors still present limitations to their practical use, such as achieving only transient transgene expression and a risk of insertional mutations.
Yusuke Yamamoto +5 more
doaj +1 more source
Mechanisms and Concepts in RNA Virus Population Dynamics and Evolution.
Annual Review of Virology, 2018 RNA viruses are unique in their evolutionary capacity, exhibiting high mutation rates and frequent recombination. They rapidly adapt to environmental changes, such as shifts in immune pressure or pharmacological challenge.
Patrick T. Dolan +2 more
semanticscholar +1 more source
KSHV ORF57, a Protein of Many Faces
Viruses, 2015 Kaposi’s sarcoma-associated herpesvirus (KSHV) ORF57 protein (also known as mRNA transcript accumulation (Mta)) is a potent posttranscriptional regulator essential for the efficient expression of KSHV lytic genes and productive KSHV replication.
Vladimir Majerciak, Zhi-Ming Zheng
doaj +1 more source
APOBEC3-mediated restriction of RNA virus replication
Scientific Reports, 2018 APOBEC3 family members are cytidine deaminases with roles in intrinsic responses to infection by retroviruses and retrotransposons, and in the control of other DNA viruses, such as herpesviruses, parvoviruses and hepatitis B virus.
A. Milewska +7 more
semanticscholar +1 more source
Marine RNA Virus Quasispecies Are Distributed throughout the Oceans
Msphere, 2019 Very little is known about aquatic RNA virus populations and genome evolution. This is the first study that analyzes marine environmental RNA viral assemblages in an evolutionary and broad geographical context.
M. Vlok, A. Lang, C. Suttle
semanticscholar +1 more source
Multifaceted contributions of Dicer2 to arbovirus transmission by Aedes aegypti
Cell Reports, 2023 Summary: Arthropod-borne viruses (arboviruses) transmitted by Aedes aegypti mosquitoes are an increasing threat to global health. The small interfering RNA (siRNA) pathway is considered the main antiviral immune pathway of insects, but its effective ...
Sarah Hélène Merkling +11 more
doaj
A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus
bioRxiv, 2018 Mutation rates can evolve through genetic drift, indirect selection due to genetic hitchhiking, or direct selection on the physicochemical cost of high fidelity. However, for many systems, it has been difficult to disentangle the relative impact of these
W. Fitzsimmons +8 more
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source