Results 31 to 40 of about 447,697 (355)

Cloned defective interfering influenza virus protects ferrets from pandemic 2009 influenza A virus and allows protective immunity to be established [PDF]

, 2012
Influenza A viruses are a major cause of morbidity and mortality in the human population, causing epidemics in the winter, and occasional worldwide pandemics.
Carroll, Miles W., Cheung, Linda, Dimmock, N. J., Dove, Brian K., Easton, A. J. (Andrew J.), Hallis, Bassam, Marriott, Anthony C., Meng, Bo, Scott, P. D. (Paul D.), Taylor, Irene   +9 more
core   +3 more sources

Virus-host protein-protein interactions as molecular drug targets for arboviral infections

Frontiers in Virology, 2022
Arboviruses have the potential to spread quickly and cause a global health emergency. These are RNA viruses that use RNA-dependent RNA polymerase (RdRp) for their replication. RdRp lacks proofreading activity, leading to high error rates, low replicative
Mandar Bhutkar, Vishakha Singh, Preeti Dhaka, Shailly Tomar   +3 more
doaj   +1 more source

RNA Virus Gene Signatures Detected in Patients With Cardiomyopathy After Chemotherapy; A Pilot Study

Frontiers in Cardiovascular Medicine, 2022
BackgroundViral infections are pervasive and leading causes of myocarditis. Immune-suppression after chemotherapy increases opportunistic infections, but the incidence of virus-induced myocarditis is unknown.ObjectiveAn unbiased, blinded screening for ...
Kyle Varkoly, Kyle Varkoly, Shaoyuan Tan, Roxana Beladi, Roxana Beladi, David Fonseca, Isabela Rivabem Zanetti, Simona Kraberger, Chintan Shah, Jordan R. Yaron, Jordan R. Yaron, Liqiang Zhang, Michael Juby, Ayman Fath, Sriram Ambadapadi, Melanie House, Paul Maranian, Carl J. Pepine, Arvind Varsani, Arvind Varsani, Jan Moreb, Stacey Schultz-Cherry, Alexandra R. Lucas, Alexandra R. Lucas, Alexandra R. Lucas   +24 more
doaj   +1 more source

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models [PDF]

, 2010
Chimpanzees represent the only animal model for studies of the natural history of hepatitis C virus (HCV). To generate virus stocks of important HCV variants, we infected chimpanzees with HCV strains of genotypes 1-6 and determined the infectivity titer ...
Bukh, Jens, Eder, Gerald, Engle, Ronald E, Feinstone, Stephen M, Govindarajan, Sugantha, Krawczynski, Krzysztof, Leroux-Roels, Geert, Meuleman, Philip, Miller, Roger H, Purcell, Robert H, Satterfield, William C, Tellier, Raymond   +11 more
core   +1 more source

Molecular Insights into the Flavivirus Replication Complex

Viruses, 2021
Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever viruses.
Kaïn van den Elsen, Jun Ping Quek, Dahai Luo   +2 more
doaj   +1 more source

Nucleotide bias of DCL and AGO in plant anti-virus gene silencing [PDF]

, 2010
Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing ...
Dalmay, Tamas, Ho, Thien, Huang, Linfeng, Li, Zhigang, Ohshima, Kazusato, Pallett, Denise W., Walsh, John A., Wang, Hui, Wang, Liang   +8 more
core   +1 more source

SARS-CoV-2 virus RNA sequence classification and geographical analysis with convolutional neural networks approach [PDF]

, 2020
Covid-19 infection, which spread to the whole world in December 2019 and is still active, caused more than 250 thousand deaths in the world today. Researches on this subject have been focused on analyzing the genetic structure of the virus, developing vaccines, the course of the disease, and its source.
arxiv   +1 more source

Use of Unamplified RNA/cDNA–Hybrid Nanopore Sequencing for Rapid Detection and Characterization of RNA Viruses

Emerging Infectious Diseases, 2016
Nanopore sequencing, a novel genomics technology, has potential applications for routine biosurveillance, clinical diagnosis, and outbreak investigation of virus infections. Using rapid sequencing of unamplified RNA/cDNA hybrids, we identified Venezuelan
Andy Kilianski, Pierce A. Roth, Alvin T. Liem, Jessica M. Hill, Kristen L. Willis, Rebecca D. Rossmaier, Andrew V. Marinich, Michele N. Maughan, Mark A. Karavis, Jens H. Kuhn, Anna N. Honko, C. Nicole Rosenzweig   +11 more
doaj   +1 more source

Functional analysis of the N-terminal basic motif of a eukaryotic satellite RNA virus capsid protein in replication and packaging [PDF]

Scientific Reports 2016; 6: 26328, 2016
Efficient replication and assembly of virus particles are integral to the establishment of infection. In addition to the primary role of the capsid protein (CP) in encapsidating the RNA progeny, experimental evidence on positive sense single-stranded RNA viruses suggests that the CP also regulates RNA synthesis. Here, we demonstrate that replication of
arxiv   +1 more source

Exosomes and Their Role in the Life Cycle and Pathogenesis of RNA Viruses

Viruses, 2015
Exosomes are membrane-enclosed vesicles actively released into the extracellular space, whose content reflect the physiological/pathological state of the cells they originate from.
Harendra Singh Chahar, Xiaoyong Bao, Antonella Casola   +2 more
doaj   +1 more source