Results 201 to 210 of about 369,072 (266)

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, EarlyView.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Diversity of RNA Viruses and Circular Viroid-like Elements in <i>Heterobasidion</i> spp. in Near-Natural Forests of Bosnia and Herzegovina. [PDF]

Viruses
Dálya LB, Hejna O, de la Peña M, Stanivuković Z, Kudláček T, Botella L.   +5 more
europepmc   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

In Vitro Synergistic Antiviral Effects of β-D-N4-hydroxycytidine and Teriflunomide in Combination against a Broad Range of RNA Viruses. [PDF]

J Med Virol
Sirihongthong T, Jitobaom K, Boonarkart C, Thongon S, Auewarakul P.   +4 more
europepmc   +1 more source

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

Selective Diversity in RNA Viruses: Do They Know How to Evolve? A Hypothesis. [PDF]

Bioessays
Nemchinov LG.
europepmc   +1 more source

Enormous diversity of RNA viruses in economic crustaceans. [PDF]

mSystems
Dong X, Meng F, Zhou C, Li J, Hu T, Wang Y, Wang G, Luo J, Li X, Liu S, Huang J, Shi W.   +11 more
europepmc   +1 more source

Multiplex detection of respiratory RNA viruses without amplification based on CRISPR-Cas13a immunochromatographic test strips. [PDF]

Virol J
Wang T, Jiang W, Huang Z, Yuan Z, Chen Z, Lin J.   +5 more
europepmc   +1 more source

Reconceptualizing transcriptional slippage in plant RNA viruses. [PDF]

mBio
Valli AA, Domingo-Calap ML, González de Prádena A, García JA, Cui H, Desbiez C, López-Moya JJ.   +6 more
europepmc   +1 more source

Oncogenic RNA viruses.

CA: a cancer journal for clinicians, 1973
D W, Allen, P, Cole
openaire   +1 more source