Results 91 to 100 of about 7,640,682 (253)

Pioneering role of RNA in the early evolution of life [PDF]

Genetics and Molecular Biology
The catalytic, regulatory and structural properties of RNA, combined with their extraordinary ubiquity in cellular processes, are consistent with the proposal that this molecule played a much more conspicuous role in heredity and metabolism during the ...
Israel Muñoz-Velasco, Adrián Cruz-González, Ricardo Hernández-Morales, José Alberto Campillo-Balderas, Wolfgang Cottom-Salas, Rodrigo Jácome, Alberto Vázquez-Salazar   +6 more
doaj   +1 more source

The Impact of Mutant p53 in the Non-Coding RNA World

Biomolecules, 2020
Long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), micro RNAs (miRNAs), and extracellular RNAs (exRNAs) are new groups of RNAs with regulation activities that have low or no protein-coding ability.
Silvia Di Agostino
doaj   +1 more source

Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs [PDF]

, 2010
Theis C, Janssen S, Giegerich R. Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs. In: Moulton V, Singh M, eds. Algorithms in Bioinformatics. 10th international workshop (WABI 2010), proceedings. Lecture Notes in Bioinformatics. Vol
Corinna Theis, Theis, Corinna, Moulton, Vincent, Singh, Mona, Stefan Janssen, Janssen, Stefan ; https://orcid.org/, Robert Giegerich, Giegerich, Robert   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry

, 2012
The VapBC toxin-antitoxin (TA) family is the largest of nine identified TA families. The toxin, VapC, is a metal-dependent ribonuclease that is inhibited by its cognate antitoxin, VapB. Although the VapBCs are the largest TA family, little is known about
Cook, Gregory M., Mackay, Joel, Cursons, Raymond T., Duyvestyn, Johanna Maria, Mckenzie, Joanna L., Smith, Tony C., Bendak, Katerina, Smith, Tony, Cursons, R. A.Y., Mackay, Joel P., Arcus, Vickery L., Duyvestyn, Johanna M., McKenzie, Joanna Leigh, https://orcid.org/   +13 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Comparative analysis of RNA families reveals distinct repertoires for each domain of life.

PLoS Computational Biology, 2012
The RNA world hypothesis, that RNA genomes and catalysts preceded DNA genomes and genetically-encoded protein catalysts, has been central to models for the early evolution of life on Earth.
Marc P Hoeppner, Paul P Gardner, Anthony M Poole   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Origin & influence of autocatalytic reaction networks at the advent of the RNA world

Research on the origin of life investigates the transition from abiotic chemistry to the emergence of biology, with the 'RNA world hypothesis' as the leading theory. RNA's dual role in storage and catalysis suggests its importance in this narrative.
Roy, Raktim N., Zorc, Stephen A.
core   +1 more source

Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis [PDF]

, 2019
Eukaryotic ribosome biogenesis is a highly orchestrated process involving numerous assembly factors including ATP-dependent RNA helicases. The DEAH helicase DHX37 (Dhr1 in yeast) is activated by the ribosome biogenesis factor UTP14A to facilitate ...
van den Heuvel, Jasmin, Jinek, Martin; https://orcid.org/, Boneberg, Franziska M, Kutay, Ulrike; https://orcid.org/, Kobel, Lena, Bammert, Lukas, Bargsten, Katja, Brandmann, Tobias, Kobel L, Boneberg, Franziska M., Kutay, Ulrike, van den Heuvel J, Kutay, Ulrike (author), Bargsten K, van den Heuvel, Jasmin (author), Jinek, Martin, Bammert, Lukas (author), Bargsten, Katja (author), Brandmann, Tobias (author), Boneberg, Franziska M. (author), Jinek, Martin (author), Boneberg FM, Jinek M, Bammert L, Kobel, Lena (author), Brandmann T, Kutay U   +26 more
core   +1 more source