Results 71 to 80 of about 837,608 (280)
, 2011 Grasping the fruits of "emerging technologies" is an objective of many government priority programs in a knowledge-based and globalizing economy. We use the publication records (in the Science Citation Index) of two emerging technologies to study the ...
Barabási +87 more
core +2 more sources
Point-of-care screening for a current Hepatitis C virus infection: influence on uptake of a concomitant offer of HIV screening [PDF]
, 2018 Eliminating hepatitis C as a public health threat requires an improved understanding of how to increase testing uptake. We piloted point-of-care testing (POCT) for a current HCV infection in an inner-city Emergency Department (ED) and assessed the ...
AL Cox +19 more
core +4 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tag mechanism as a strategy for the RNA replicase to resist parasites in the RNA world. [PDF]
PLoS ONE, 2017 The idea that life may have started with an "RNA world" is attractive. Wherein, a crucial event (perhaps at the very beginning of the scenario) should have been the emergence of a ribozyme that catalyzes its own replication, i.e., an RNA replicase ...
Sanmao Wu +6 more
doaj +1 more source
The RNA world: hypotheses, facts and experimental results. [PDF]
, 2005 A biochemical world that would have existed before the contemporary DNA-RNA-Protein world, and baptized in 1986 "The RNA World" by Walter Gilbert, such a world had already been proposed during the preceding decades by Carl Woese, Francis Crick and Leslie
Haenni, Anne-Lise +1 more
core +1 more source
Climate Change and invasibility of the Antarctic benthos [PDF]
, 2007 Benthic communities living in shallow-shelf habitats in Antarctica (<100-m depth) are archaic in their structure and function. Modern predators, including fast-moving, durophagous (skeleton-crushing) bony fish, sharks, and crabs, are rare or absent ...
A Brandt +62 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Frequency of RNA–RNA interaction in a model of the RNA World [PDF]
RNA, 2006 The RNA World model for prebiotic evolution posits the selection of catalytic/template RNAs from random populations. The mechanisms by which these random populations could be generated de novo are unclear. Non-enzymatic and RNA-catalyzed nucleic acid polymerizations are poorly processive, which means that the resulting short-chain RNA population could ...
John C, Striggles +2 more
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Chiral polymerisation and the RNA world [PDF]
, 2005 The purpose of this paper is to review two mathematical models: one for the formation of homochiral polymers from an originally chirally symmetric system; and the other, to show how, in an RNA-world scenario, RNA can simultaneously act both as ...
Coveney, Peter V., Wattis, Jonathan A.D.
core