Results 121 to 130 of about 836,536 (329)

Evolution in an RNA World [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2009
A long-standing research goal has been to develop a self-sustained chemical system that is capable of undergoing Darwinian evolution. The notion of primitive RNA-based life suggests that this goal might be achieved by constructing an RNA enzyme that catalyzes the replication of RNA molecules, including the RNA enzyme itself.
openaire   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

RNA structure prediction: progress and perspective

, 2014
Many recent exciting discoveries have revealed the versatility of RNAs and their importance in a variety of cellular functions which are strongly coupled to RNA structures.
Shi, Ya-Zhou, Tan, Zhi-Jie, Wang, Feng-Hua, Wu, Yuan-Yan   +3 more
core   +1 more source

There is a world beyond protein mutations: the role of non‐coding RNAs in melanomagenesis [PDF]

, 2013
Rolf Swoboda, Meenhard Herlyn
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Mini-ribozymes and freezing environment: a new scenario for the early RNA world

, 2005
International audienceThe RNA World hypothesis states that the present-day life, which is based on DNA genomes and protein enzymes, was preceded by a simpler life form based primarily on RNA.
Vlassov, A. V.
core   +1 more source

Modeling prebiotic catalysis with nucleic acid-like polymers and its implications for the proposed RNA world [PDF]

, 2004
Seergazhi G. Srivatsan
openalex   +1 more source

The 2008 Retrovirology Prize: Ben Berkhout and his RNA world

Retrovirology, 2008
Ben Berkhout wins the 2008 Retrovirology Prize.
Jeang Kuan-Teh
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

RNA World research—still evolving [PDF]

RNA, 2015
One step forward, two steps back. That's how laboratory research seems to progress for most grad students and postdocs from week to week. Yet, when we step back and look at how far the RNA field has progressed in the 20 years since the RNA journal was born, we get a very different perspective. The international community of RNA scientists, through hard
openaire   +2 more sources