Results 171 to 180 of about 778,146 (302)
Prebiotic chiral transfer from self-aminoacylating ribozymes may favor either handedness
Modern life is essentially homochiral, containing D-sugars in nucleic acid backbones and L-amino acids in proteins. Since coded proteins are theorized to have developed from a prebiotic RNA World, the homochirality of L-amino acids observed in all known ...
Josh Kenchel+10 more
doaj +1 more source
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova+26 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero+8 more
wiley +1 more source
Evolution towards increasing complexity through functional diversification in a protocell model of the RNA world. [PDF]
Roy S, Sengupta S.
europepmc +1 more source
Pharmacogenomics of the RNA World: Structural RNA Polymorphisms in Drug Therapy [PDF]
Wolfgang Sadée+6 more
openalex +1 more source
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li+12 more
wiley +1 more source
The many faces of RNA-based RNase P, an RNA-world relic. [PDF]
Phan HD+3 more
europepmc +1 more source
Primordial soup or vinaigrette: did the RNA world evolve at acidic pH? [PDF]
Harold S. Bernhardt, Warren P. Tate
openalex +1 more source