Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
The routes of emergence of life from LUCA during the RNA and viral world [PDF]
, 2015 Sohan Jheeta
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Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran +3 more
wiley +1 more source
TetraRNA, a tetra-class machine learning model for deciphering the coding potential derivation of RNA world. [PDF]
Comput Struct Biotechnol JBai H +7 more
europepmc +1 more source
Case for an RNA–prion world: a hypothesis based on conformational diversity
, 2011 Param Priya Singh, Anirban Banerji
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Circular RNA: an emerging key player in RNA world [PDF]
, 2016 Xianwen Meng +5 more
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The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, EarlyView.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source
Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes. [PDF]
ChembiochemDécout JL, Maurel MC.
europepmc +1 more source
Meteorites and the RNA World: A Thermodynamic Model of Nucleobase Synthesis within Planetesimals [PDF]
, 2016 Ben K. D. Pearce, Ralph E. Pudritz
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