Results 281 to 290 of about 778,146 (302)
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
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Trends in Biochemical Sciences, 1999
A popular theory of life's origins states that the first biocatalysts were not made of protein but were made of RNA or a very similar polymer. Experiments are beginning to confirm that the catalytic abilities of RNA are compatible with this 'RNA world' hypothesis. For example, RNA can synthesize short fragments of RNA in a template-directed fashion and
Peter J. Unrau, David P. Bartel
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A popular theory of life's origins states that the first biocatalysts were not made of protein but were made of RNA or a very similar polymer. Experiments are beginning to confirm that the catalytic abilities of RNA are compatible with this 'RNA world' hypothesis. For example, RNA can synthesize short fragments of RNA in a template-directed fashion and
Peter J. Unrau, David P. Bartel
openaire +3 more sources
Science-Business eXchange, 2014
RNA-based drugs have redefined the universe of tractable targets by putting virtually anything that is gene encoded within reach of a disease-modifying agent, turning RNA into the biotech industry's de facto third drug modality.
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RNA-based drugs have redefined the universe of tractable targets by putting virtually anything that is gene encoded within reach of a disease-modifying agent, turning RNA into the biotech industry's de facto third drug modality.
openaire +2 more sources
RNA–DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World
Angewandte Chemie, 2016AbstractThe RNA world hypothesis posits that DNA and proteins were later inventions of early life, or the chemistry that gave rise to life. Most scenarios put forth for the emergence of DNA assume a clean separation of RNA and DNA polymer, and a smooth transition between RNA and DNA.
Jesse V. Gavette +3 more
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Current Opinion in Chemical Biology, 1999
Before large, specific peptides could be made, in an RNA world our ancestors may have used an RNA-like molecule for both catalysis and information storage. Taken together, RNA activities suggest RNA could have performed most of the essential informational functions of an ancient organism (i.e. those functions most similar to RNA's role today).
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Before large, specific peptides could be made, in an RNA world our ancestors may have used an RNA-like molecule for both catalysis and information storage. Taken together, RNA activities suggest RNA could have performed most of the essential informational functions of an ancient organism (i.e. those functions most similar to RNA's role today).
openaire +3 more sources
New England Journal of Medicine, 2018
RNA Biology and Parity at the Bench The 2018 Lasker–Koshland Special Achievement Award in Medical Science, announced September 11, goes to Joan A. Steitz for her pioneering discoveries in RNA biology and her work toward better representation of women and minorities in scientific research.
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RNA Biology and Parity at the Bench The 2018 Lasker–Koshland Special Achievement Award in Medical Science, announced September 11, goes to Joan A. Steitz for her pioneering discoveries in RNA biology and her work toward better representation of women and minorities in scientific research.
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2012
Alternative splicing is a key element of eukaryotic gene expression. Almost all polymerase II transcripts are alternatively spliced. RNA is chemically and structurally more flexible than DNA, and can act as a catalyst. RNA is an active player in mediating genetic information, not just a static messenger.
BURATTI, EMANUELE +2 more
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Alternative splicing is a key element of eukaryotic gene expression. Almost all polymerase II transcripts are alternatively spliced. RNA is chemically and structurally more flexible than DNA, and can act as a catalyst. RNA is an active player in mediating genetic information, not just a static messenger.
BURATTI, EMANUELE +2 more
openaire +3 more sources
Trends in Biochemical Sciences, 2000
The track record of X-rays in revealing life’s inner secrets is the envy of other photons. The most profound mysteries that have been investigated with them have been revealed first to the bravest and the most persistent people on earth. Few dared to purify a 1 500 000 Da complex containing 30 or more polypeptides and 990 000 Da of RNA. Fewer succeeded
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The track record of X-rays in revealing life’s inner secrets is the envy of other photons. The most profound mysteries that have been investigated with them have been revealed first to the bravest and the most persistent people on earth. Few dared to purify a 1 500 000 Da complex containing 30 or more polypeptides and 990 000 Da of RNA. Fewer succeeded
openaire +3 more sources