Results 71 to 80 of about 298 (200)
Origin & influence of autocatalytic reaction networks at the advent of the RNA world
RNA BiologyResearch on the origin of life investigates the transition from abiotic chemistry to the emergence of biology, with the ‘RNA world hypothesis’ as the leading theory. RNA’s dual role in storage and catalysis suggests its importance in this narrative.
Stephen A. Zorc, Raktim N. Roy
doaj +1 more source
Cryosphere and Psychrophiles: Insights into a Cold Origin of Life?
Life, 2017 Psychrophiles thrive permanently in the various cold environments on Earth. Their unsuspected ability to remain metabolically active in the most extreme low temperature conditions provides insights into a possible cold step in the origin of life.
Georges Feller
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
RNA Back and Forth: Looking through Ribozyme and Viroid Motifs
Viruses, 2019 Current cellular facts allow us to follow the link from chemical to biochemical metabolites, from the ancient to the modern world. In this context, the “RNA world„ hypothesis proposes that early in the evolution of life, the ribozyme was ...
Marie-Christine Maurel +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Biology Direct, 2009 Background The accompanying article (A.Y. Mulkidjanian, Biology Direct 4:26) puts forward a detailed hypothesis on the role of zinc sulfide (ZnS) in the origin of life on Earth.
Mulkidjanian Armen Y, Galperin Michael Y
doaj +1 more source
ChemBioChem, 2015 In the spring of the world: Reductive homologation of cyanidic precursors creates the carbon scaffold for multiple classes of biologically relevant compounds. This chemistry underpins a scenario for the formation of a protometabolism on the way to an RNA world.
openaire +3 more sources
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
NASA's RNA World Experiments and the Matter World Hypothesis: A Comprehensive Critique
The RNA World Hypothesis (RWH), positing that self-replicating RNA molecules were the precursors to life, has been a cornerstone of NASA’s Astrobiology and Exobiology programs. Despite extensive research, no NASA-funded project has achieved a fully autonomous, self-replicating RNA-based protocell, revealing significant limitations.
openaire +4 more sources