Results 151 to 160 of about 267,874 (284)
iLABMED, EarlyView.We identified FOXA2 as a key regulator of lymph node metastasis in thyroid cancer, which controls cancer cell aggressiveness. FOXA2 knockdown promotes metastasis by enhancing tumor cell migration and, importantly, by inducing T‐cell apoptosis through a CCL2/LCN2‐mediated pathway. Created with BioGDP.com.
Ping Yang +6 more
wiley +1 more source
N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential
iNew Medicine, EarlyView.ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen +6 more
wiley +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo +8 more
wiley +1 more source
Regulatory mechanisms of reproduction in locusts and grasshoppers
New Plant Protection, EarlyView.Regulatory networks composed of numerous coding and noncoding genes play crucial roles in the reproduction of locusts and grasshoppers. This review integrates mechanistic advances in reproductive regulation, highlighting environmentally adaptive pathways and providing prospective targets for eco‐friendly pesticides.
Jing He, Jiliang Wang, Xinran Wang
wiley +1 more source
Genetically Modified Wheat, Wheat Intolerance, and Food Safety Concerns
European Medical Journal Allergy & Immunology, 2018 Wheat intolerance is a common problem for certain individuals. A gluten-free diet is the only option for people with wheat-associated disorders (WAD) to manage their condition.
Atul Munish Chander +2 more
doaj
New Plant Protection, EarlyView.Flight in female beet webworms (Loxostege sticticalis) promotes an increase in feeding, thereby enhancing abdominal energy reserves. Following flight, the flight muscles undergo accelerated histolysis, and the energy substances undergoing histolysis are redirected to the ovaries. These two processes collectively promote ovarian development.
Yu Gao +5 more
wiley +1 more source
New Plant Protection, EarlyView.We identified and characterized the gustatory and ionotropic receptors of Cydia pomonella using transcriptomics and in silico approaches, linking candidate sugar receptors to larval feeding attraction. Functional assays and behavioral tests highlighted isoquercitrin as a key feeding stimulant, providing a foundation for olfactory‐ and taste‐based pest ...
Chenyun Ding +6 more
wiley +1 more source
Genetic Basis of Increased Lifespan and Postponed Senescence in Drosophila melanogaster
G3: Genes, Genomes, Genetics, 2020 Grace A. Parker +5 more
doaj +1 more source
Breeding for multi‐stress resilience in crops: Myth or possibility?
PLANTS, PEOPLE, PLANET, EarlyView.Climate change threatens millions of farmers worldwide by exposing crops to multiple concurrent or sequential environmental stresses such as drought, heat, waterlogging, and diseases. Although crops have long been selected under naturally occurring multi‐stress conditions, breeding pipelines largely focus on optimal or single‐stress environments ...
Hamid Khazaei +2 more
wiley +1 more source
Pest Management Science, EarlyView.RNA degradomics revealed dsProsβ1‐derived siRNA‐mediated mRNA cleavage events, mainly at uracil‐guanine and adenine‐adenine pairs. Proteasome inhibition via dsProsβ1 increased mitochondrial and cytoskeletal proteins while reducing translation‐related and mRNA‐binding proteins.
Doga Cedden +3 more
wiley +1 more source