Results 171 to 180 of about 323,847 (388)
Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy
Advanced Science, EarlyView.Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou +7 more
wiley +1 more source
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
Nature, 2003 R. Kamath +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.At 2 5 °C, thermal activation initiates: i) CcIav/CcNan heterotetramer assembly → Ca2⁺ influx; ii) CcPKCα phosphorylation → AKH signaling potentiation; iii) CcAKH1 binding to membrane‐localized CcAKHR → energy mobilization (lipid catabolism/glycogenolysis) and vitellogenin transport via follicular patency; iv) Oocyte maturation → summer‐form nymph ...
Jianying Li +6 more
wiley +1 more source
Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]
, 2012 Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core
Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts
Advanced Science, EarlyView.This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu +8 more
wiley +1 more source
D-RNAi (Messenger RNA-antisense DNA Interference) as a Novel Defense System Against Cancer and Viral Infections. [PDF]
, 2001 Shuei‐Liong Lin +4 more
openalex +1 more source
Advanced Science, EarlyView.Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim +10 more
wiley +1 more source