Results 171 to 180 of about 330,568 (380)

RNAi Development

PLoS Computational Biology, 2007
Mark Gerstein, Shawn M Douglas
openaire   +4 more sources

Single‐cell sequencing reveals potential novel insights into appendage‐patterning and joint‐development in a spider

Developmental Dynamics, EarlyView.
Abstract Background Jointed appendages represent one of the key innovations of arthropods, and thus understanding the development and evolution of these structures is important for the understanding of the evolutionary success of Arthropoda. In this paper, we analyze a cell cluster that was identified in a previous single‐cell sequencing (SCS ...
Brenda I. Medina‐Jiménez, Graham E. Budd, Ralf Janssen   +2 more
wiley   +1 more source

OfftargetFinder: a web tool for species-specific RNAi design [PDF]

, 2015
Robert T. Good, Tincy Varghese, John F. Golz, D.A. Russell, Alexie Papanicolaou, Owain R. Edwards, Charles Robin   +6 more
openalex   +1 more source

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

Pathogen Response Genes Mediate Caenorhabditis elegans Innate Immunity

, 2012
Innate immunity is crucial in the response and defense against pathogens for invertebrates and vertebrates alike. The soil nematode Caenorhabditis elegans is a useful model to study the eukaryotic innate immune response to microbial pathogenesis.
Anthony, Hannah L.
core  

Tumor‐Intrinsic Forkhead Box A2 Regulates the Lymph Node Metastasis of Papillary Thyroid Carcinoma by Regulating T‐Cell Apoptosis

iLABMED, EarlyView.
We identified FOXA2 as a key regulator of lymph node metastasis in thyroid cancer, which controls cancer cell aggressiveness. FOXA2 knockdown promotes metastasis by enhancing tumor cell migration and, importantly, by inducing T‐cell apoptosis through a CCL2/LCN2‐mediated pathway. Created with BioGDP.com.
Ping Yang, Xueying Zhang, Wen Deng, Fangning Gao, Shujia Peng, Guoqiang Bao, Lijuan Yuan   +6 more
wiley   +1 more source

Identification and functional analysis of six DNAJ genes from Myzus persicae (Hemiptera: Aphididae) in response to UV-B stress

European Journal of Entomology
Ultraviolet B (UV-B) is a significant environmental factor affecting insect development, survival, and reproduction. DNAJ proteins are molecular chaperones found ubiquitously in insects that are crucial for their adaptation to environmental stresses ...
Long-Chun HE, Jian-Yu MENG, Guy SMAGGHE, Chang-Li YANG, Xue TANG, Chang-Yu ZHANG   +5 more
doaj   +1 more source

LIN‐24 as a Molecular Switch: Dual Cytotoxic and Cytoprotective Roles of an Aerolysin‐Like Protein in C. elegans

Journal of Applied Toxicology, EarlyView.
ABSTRACT LIN‐24, an aerolysin‐like pore‐forming protein in Caenorhabditis elegans, exemplifies how ancient cytolytic mechanisms have evolved into regulated cellular processes. Initially identified for inducing nonapoptotic, engulfment‐dependent cell death in vulval precursor cells, LIN‐24 has emerged as a multifunctional regulator of metabolism, stress
Sharoen Yu Ming Lim
wiley   +1 more source

Functional analysis of two SfHsp90 genes in response to high temperature and insecticide stress in Spodoptera frugiperda (Lepidoptera: Noctuidae)

European Journal of Entomology
Spodoptera frugiperda, a worldwide pest, can feed on 353 crops species, including corn, rice, and sorghum. It is highly adaptable to various environments.
Hong-Yun RUAN, Lv ZHOU, Lei YANG, Jian-Yu MENG, Chang-Yu ZHANG   +4 more
doaj   +1 more source

Asymmetry in the Assembly of the RNAi Enzyme Complex

Cell, 2003
D. Schwarz, G. Hutvagner, T. Du, Zuoshang Xu, N. Aronin, P. Zamore   +5 more
semanticscholar   +1 more source