Results 311 to 320 of about 195,676 (344)
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Current Pharmaceutical Design, 2014
RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. In protozoan parasites like Plasmodium, Toxoplasma, Entamoeba, Giardia, Trypanosoma, and Leishmania, this set of ...
Mueller, Ann-Kristin +2 more
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RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. In protozoan parasites like Plasmodium, Toxoplasma, Entamoeba, Giardia, Trypanosoma, and Leishmania, this set of ...
Mueller, Ann-Kristin +2 more
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Engineering lymphocytes with RNAi
Advanced Drug Delivery Reviews, 2019Lymphocytes are the gatekeepers of the body's immune system and are involved in pathogenesis if their surveillance is stalled by inhibitory molecules or when they act as mediators for viral entry. Engineering lymphocytes in order to restore their functions is an unmet need in immunological disorders, cancer and in lymphotropic viral infections ...
Ramishetti, Srinivas, Peer, Dan
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Nature Methods, 2012
Rationally designed RNAs that work with the bacterial immune response allow targeted gene silencing in prokaryotes.
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Rationally designed RNAs that work with the bacterial immune response allow targeted gene silencing in prokaryotes.
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Current scenario of RNAi-based hemipteran control.
Pest Management Science, 2020RNA interference (RNAi) is a homology-dependent gene silencing mechanism that is a feasible and sustainable avenue for the management of hemipteran pests.
R. Jain +3 more
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Current Protocols in Bioinformatics, 2004
AbstractRNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and application of this knowledge to the construction of a gene‐silencing library. This unit discusses approaches to rational design of this library and its use in experiments. It
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AbstractRNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and application of this knowledge to the construction of a gene‐silencing library. This unit discusses approaches to rational design of this library and its use in experiments. It
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2014
Typically, genes are delivered to a cell to increase the expression of a protein. RNA interference (RNAi), however, is used to lower or eliminate the production of a protein. In a gene delivery sense, the technology is very similar to transfection or transduction.
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Typically, genes are delivered to a cell to increase the expression of a protein. RNA interference (RNAi), however, is used to lower or eliminate the production of a protein. In a gene delivery sense, the technology is very similar to transfection or transduction.
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Current Protocols in Molecular Biology, 2005
AbstractRNA silencing in plants is a rapid and facile approach for assignment of gene function and virus resistance. It allows selective RNA degradation through a mechanism that is given specificity by short interfering RNAs. The RNA silencer sequences are normally delivered as transgenes or a part of virus‐vectors.
Joanne Chory +2 more
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AbstractRNA silencing in plants is a rapid and facile approach for assignment of gene function and virus resistance. It allows selective RNA degradation through a mechanism that is given specificity by short interfering RNAs. The RNA silencer sequences are normally delivered as transgenes or a part of virus‐vectors.
Joanne Chory +2 more
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RNAi-based therapeutics and tumor targeted delivery in cancer.
Advanced Drug Delivery Reviews, 2022Goknur Kara, G. Calin, B. Ozpolat
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Current Opinion in Chemical Biology, 2001
In many species, double-stranded RNA can specifically and effectively silence genes. This newly discovered biological phenomenon, called RNA interference (RNAi), has practical implications for functional genomics. As shown by two recent reports, RNAi provides a rapid method to test the function of genes in the nematode Caenorhabditis elegans; most of ...
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In many species, double-stranded RNA can specifically and effectively silence genes. This newly discovered biological phenomenon, called RNA interference (RNAi), has practical implications for functional genomics. As shown by two recent reports, RNAi provides a rapid method to test the function of genes in the nematode Caenorhabditis elegans; most of ...
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Methods, 2011
RNA interference (RNAi)-mediated gene knockdown has developed into a routine method to assess gene function in cultured mammalian cells in a fast and easy manner. For the use of RNAi in mice, short hairpin (sh) RNAs expressed stably from the genome are a fast alternative to conventional knockout approaches.
Ralf Kühn +3 more
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RNA interference (RNAi)-mediated gene knockdown has developed into a routine method to assess gene function in cultured mammalian cells in a fast and easy manner. For the use of RNAi in mice, short hairpin (sh) RNAs expressed stably from the genome are a fast alternative to conventional knockout approaches.
Ralf Kühn +3 more
openaire +2 more sources