Results 311 to 320 of about 323,847 (388)
Enhancing Late‐Life Survival and Mobility via Mitohormesis by Reducing Mitochondrial Calcium Levels
Aging Cell, EarlyView.RNAi knockdown (KD) of mcu‐1 or mitoxantrone treatment lowers mitochondrial Ca2+, extends lifespan, and preserves motility during aging. Benefits require early intervention and involve a transient ROS increase that activates a pmk‐1, daf‐16, and skn‐1 pathway, enhancing stress defense and mitochondrial integrity while reducing early‐life survival ...
Doruntina Bresilla +13 more
wiley +1 more source
Nuclear destabilisation – a possible genesis of cancer?
Biological Reviews, EarlyView.ABSTRACT This review examines the increasingly prominent role of mechanics within cancer formation and progression. The extremely varied and contradictory genetic landscape of cancer is in stark contrast to the seemingly universal mechanical characteristics of cancer cells and their tumour microenvironment, and mechanics may be a principal unifying ...
Daniel D. Scott +4 more
wiley +1 more source
Assessment of Potential Toxic Effects of RNAi-Based Transgenic Cotton on the Non-Target Predator <i>Harmonia axyridis</i>. [PDF]
Biology (Basel)Yao H, Xu H, Yang J, Ma W.
europepmc +1 more source
Cancer Science, EarlyView.This study examines the deployment of T‐cell receptor (TCR) bispecific proteins administered through mesenchymal stem cells (MSCs) as a therapeutic strategy for pulmonary carcinoma. Utilizing a humanized murine model, TCR bispecific proteins exhibited potent cytotoxicity against pulmonary carcinoma cell lines, with MSCs proficiently localizing to the ...
Teng Wei +5 more
wiley +1 more source
The down-regulation of MsWOX13-2 promotes enhanced waterlogging resilience in alfalfa. [PDF]
Plant JSubedi U +7 more
europepmc +1 more source
Conservation Biology, EarlyView.Abstract Identifying refugia from emerging threats is vital to ensure the persistence of rare and threatened species, but modeling habitat distribution for these species is challenging and the role of people in refuge management is rarely considered. Myrtle rust is an emerging infectious disease that represents a grave threat to the rare wetland tree ...
Sarah M. Herbert +7 more
wiley +1 more source
A novel intracellular signaling pathway elicited by DM9CP-6 regulates immune responses in oysters. [PDF]
Cell Commun SignalSun J, Li Y, Liu Y, Wang L, Song L.
europepmc +1 more source
European Journal of Clinical Investigation, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) is a major global cause of liver disease, driven by obesity and insulin resistance (IR). IR promotes hepatic lipid accumulation, inflammation and mitochondrial dysfunction, accelerating MASLD progression to fibrosis, cirrhosis and hepatocellular carcinoma (HCC).
Alfredo Caturano +15 more
wiley +1 more source