Results 321 to 330 of about 195,676 (344)
Some of the next articles are maybe not open access.
Nature, 2004
The term RNAi — short for RNA interference — crops up again and again in biology research these days. This is in part because of its power as a laboratory tool, and in part because it is a widespread natural phenomenon.
Carl D. Novina, Phillip A. Sharp
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The term RNAi — short for RNA interference — crops up again and again in biology research these days. This is in part because of its power as a laboratory tool, and in part because it is a widespread natural phenomenon.
Carl D. Novina, Phillip A. Sharp
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Trends in Biotechnology, 2004
Synthetic small interfering RNA (siRNA) has become a valuable tool for investigating gene function in cell culture. This success has led to high expectations for siRNA as a tool for in vivo investigation and as a platform for therapeutic development.
Zain Paroo, David R. Corey
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Synthetic small interfering RNA (siRNA) has become a valuable tool for investigating gene function in cell culture. This success has led to high expectations for siRNA as a tool for in vivo investigation and as a platform for therapeutic development.
Zain Paroo, David R. Corey
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2011
In the last decade, much progress has been made towards a basic understanding of RNA silencing mechanisms in plants, like in animals and other eukaryotes. Many events that were already known, such as pathogen-derived resistance, posttranscriptional gene silencing, and microRNA (miRNA)-mediated regulation, were found to share a fundamentally similar ...
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In the last decade, much progress has been made towards a basic understanding of RNA silencing mechanisms in plants, like in animals and other eukaryotes. Many events that were already known, such as pathogen-derived resistance, posttranscriptional gene silencing, and microRNA (miRNA)-mediated regulation, were found to share a fundamentally similar ...
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A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
Nature, 2007G. Dietzl +13 more
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Argonaute2 Is the Catalytic Engine of Mammalian RNAi
Science, 2004Jidong Liu +9 more
semanticscholar +1 more source
Molecular BioSystems, 2006
The commercial potential of RNAi is assessed on the basis of successful translation of technology into applications in three areas: (1) drug discovery and research-currently the biggest segment; (2) potential therapeutic applications; and (3) the role of microRNA in molecular diagnostics.
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The commercial potential of RNAi is assessed on the basis of successful translation of technology into applications in three areas: (1) drug discovery and research-currently the biggest segment; (2) potential therapeutic applications; and (3) the role of microRNA in molecular diagnostics.
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The current state and future directions of RNAi-based therapeutics
Nature reviews. Drug discovery, 2019Ryan L Setten, J. Rossi, Si-ping Han
semanticscholar +1 more source
Expert Opinion on Biological Therapy, 2005
There are a dozen or so viruses that will continue to be a serious global health threat for many years to come, mainly due to their chronic nature. These include hepatitis C virus (HCV), human papillomavirus viruses (HPVs), West Nile virus and human herpes viruses (i.e., HSV, CMV, EBV, HHV-8, etc.).
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There are a dozen or so viruses that will continue to be a serious global health threat for many years to come, mainly due to their chronic nature. These include hepatitis C virus (HCV), human papillomavirus viruses (HPVs), West Nile virus and human herpes viruses (i.e., HSV, CMV, EBV, HHV-8, etc.).
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2011
Engineered "computing" biological networks are a generalization of endogenous regulatory pathways. They are intended to generate novel biological responses based on preprogrammed processing of multiple molecular signals. We have recently introduced an approach to constructing complex signal processing networks in mammalian cells using RNA interference (
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Engineered "computing" biological networks are a generalization of endogenous regulatory pathways. They are intended to generate novel biological responses based on preprogrammed processing of multiple molecular signals. We have recently introduced an approach to constructing complex signal processing networks in mammalian cells using RNA interference (
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Trends in Genetics, 2003
Just a couple of years ago, only biologists working with plants or Caenorhabditis elegans could use RNA-mediated interference (RNAi) technology to gain insight into gene function. However, the recent groundbreaking discovery that in vitro synthesized, 21- to 23-nucleotide, double-stranded RNAs can act as small interfering RNAs (siRNAs) to elicit gene ...
openaire +3 more sources
Just a couple of years ago, only biologists working with plants or Caenorhabditis elegans could use RNA-mediated interference (RNAi) technology to gain insight into gene function. However, the recent groundbreaking discovery that in vitro synthesized, 21- to 23-nucleotide, double-stranded RNAs can act as small interfering RNAs (siRNAs) to elicit gene ...
openaire +3 more sources