Results 321 to 330 of about 323,847 (388)

Integrated transcriptomic and metabolomic analyses elucidate the regulatory role of SlBEL11 in tomato fruit ripening. [PDF]

Front Plant Sci
Dong X, Lu J, Guo Y, Zhang Q, Yang Q, Peng J, Tian L.   +6 more
europepmc   +1 more source

High‐throughput screening identifies a previously undescribed checkpoint controlling mitotic progression in response to DNA damage

The FEBS Journal, EarlyView.
DNA damage can cause mitotic delay to allow DNA repair to occur. However, the mechanism underlying this is unclear. Here, we show that in response to cells entering mitosis with DNA damage, SOD1 restrains PP2a activity via oxidation of cysteine residues at the active site. This leads to a reduction in PP2a activity at the mitotic kinetochore, resulting
Nan Li, Rachel Gatenby, Thomas Walne, Caroline Daye, Steven Watson, Priya Lata, Stephen Brown, Ruth Thompson   +7 more
wiley   +1 more source

Neuromedin U Receptor NMUR3 Regulates Autophagy, Thereby Enhancing Thermal Tolerance in <i>C. elegans</i>. [PDF]

Int J Mol Sci
He L, Yang J, Wang S, Ma Y, Zou C.
europepmc   +1 more source

CRISPR‐Cas9 screen reveals that inhibition of enhancer of zeste homolog 2 sensitizes malignant T cells to dimethyl‐fumarate‐induced cell death

The FEBS Journal, EarlyView.
A genome‐wide CRISPR‐Cas9 screen identified H3K27 methylation as a key regulator of T‐cell lymphoma sensitivity to dimethyl fumarate (DMF). Specifically, inhibition of enhancer of zeste homolog 2 (EZH2) enhanced DMF‐induced cell death in malignant T cells. These results provide functional evidence for the role of EZH2 in modulating drug sensitivity and
Jan P. Teubner, Deniz Tümen, Arne Kandulski, Philipp Heumann, Patricia Mester, Elisabeth Aschenbrenner, Kirstin Pollinger, Manuela Gunckel, Barbara Volz, Tobias Hein, Paul L. Beltzig, Luisa Tengler, Florian Voll, Marina Kreutz, Claudia Kunst, Jan P. Nicolay, Martina Müller, Karsten Gülow   +17 more
wiley   +1 more source

Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex. [PDF]

PLoS Pathog
Stettler P, Aeschlimann S, Schimanski B, Schneider A.   +3 more
europepmc   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

The cell-adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth. [PDF]

Development
Spitzer DC, Sun WY, Rodríguez-Vargas A, Hariharan IK.   +3 more
europepmc   +1 more source

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, EarlyView.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source

The loss of a ClC anion channel increases life span, health span, and stress resistance by alkalinizing a pair of glial cells in <i>C. elegans</i>. [PDF]

Sci Adv
Wang L, Oliver EI, D'Urso DL, Graziano B, Bianchi L.   +4 more
europepmc   +1 more source

PU.1 and TGF‐β signaling activate the cell‐surface expression of CD103 in mast cells and dendritic cells: opposite roles of GATA2 in the expression of mucosal mast cell genes

The FEBS Journal, EarlyView.
Mucosal mast cells (MMCs) are distinguished from connective tissue MCs by the specific cell‐surface expression of integrin CD103 (αE/β7) and proteases Mcpt1 and Mcpt2. Expression of the Itgae gene (encoding αE) in MMCs is positively regulated by PU.1 and TGF‐β signaling.
Kenta Ishii, Kazuki Nagata, Niya Yamashita, Yuki Yamazaki, Yuta Akimoto, Weiting Zhao, Mariko Inoue, Naoto Ito, Kazumi Kasakura, Chiharu Nishiyama   +9 more
wiley   +1 more source