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Condition-dependent effects of knockdown of autophagy on C. elegans longevity
Hsiung KC +5 more
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Current Pharmaceutical Design, 2014
RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. In protozoan parasites like Plasmodium, Toxoplasma, Entamoeba, Giardia, Trypanosoma, and Leishmania, this set of ...
Mueller, Ann-Kristin +2 more
openaire +3 more sources
RNA interference (RNAi) has quickly proven to be an immensely useful tool for studying gene function and validation of potential drug targets in almost all organisms that possess the required set of proteins of the interference pathway. In protozoan parasites like Plasmodium, Toxoplasma, Entamoeba, Giardia, Trypanosoma, and Leishmania, this set of ...
Mueller, Ann-Kristin +2 more
openaire +3 more sources
Engineering lymphocytes with RNAi
Advanced Drug Delivery Reviews, 2019Lymphocytes are the gatekeepers of the body's immune system and are involved in pathogenesis if their surveillance is stalled by inhibitory molecules or when they act as mediators for viral entry. Engineering lymphocytes in order to restore their functions is an unmet need in immunological disorders, cancer and in lymphotropic viral infections ...
Ramishetti, Srinivas, Peer, Dan
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Nature Methods, 2012
Rationally designed RNAs that work with the bacterial immune response allow targeted gene silencing in prokaryotes.
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Rationally designed RNAs that work with the bacterial immune response allow targeted gene silencing in prokaryotes.
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Current scenario of RNAi-based hemipteran control.
Pest Management Science, 2020RNA interference (RNAi) is a homology-dependent gene silencing mechanism that is a feasible and sustainable avenue for the management of hemipteran pests.
R. Jain +3 more
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Current Protocols in Bioinformatics, 2004
AbstractRNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and application of this knowledge to the construction of a gene‐silencing library. This unit discusses approaches to rational design of this library and its use in experiments. It
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AbstractRNAi is a novel genetic tool that is poised to revolutionize the study of genetics and gene networks. Use of this tool requires knowledge of the underlying mechanisms and application of this knowledge to the construction of a gene‐silencing library. This unit discusses approaches to rational design of this library and its use in experiments. It
openaire +3 more sources