Results 41 to 50 of about 147,575 (261)
Science, 2009 Yeast Joins RNAi Club RNA interference (RNAi) silences gene expression via small interfering (si) RNAs that bind to target sequences. RNAi has been found in almost all eukaryotes examined, with the notable exception of the budding yeast, Saccharomyces cerevisiae , one of the
Drinnenberg, Ines A. +6 more
openaire +4 more sources
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1
Advanced Science, EarlyView.Chd1, the Drosophila homologue of mammalian CHD2 ‐ a gene linked to autism, epilepsy, and intellectual disability, is required for synaptic homeostatic plasticity. Chd1 in glia is necessary for the rapid induction of synaptic homeostasis, whereas Chd1 in motoneurons, muscle, and glia is critical for long‐term maintenance.
Danielle T. Morency +19 more
wiley +1 more source
In silico analyses of miRNAs that Target Odorant Binding and Chemosensory Proteins in Bemisia tabaci
Turkish Journal of Agriculture: Food Science and TechnologyThe whitefly, Bemisia tabaci, damages various crops by releasing honeydew and spreading. Although farmers and pest control experts primarily rely on insecticides to manage whiteflies, the notable issue is their tendency to develop resistance to major ...
Mehtap Bal, Sevgi Maraklı
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A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Advanced Science, EarlyView.Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
Molecular & Cellular Oncology, 2019 A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells.
Shawn T. Beug +2 more
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Advanced Science, EarlyView.Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang +21 more
wiley +1 more source
Biologia Plantarum, 2019 Sri Lankan cassava mosaic virus (SLCMV) is the principal causal agent of cassava mosaic disease in the Indian subcontinent. To gain resistance against the virus, the coat protein (CP) gene, namely the AV1 of SLCMV-Adivaram isolate, was cloned in either ...
A. GOGOI +4 more
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The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica [PDF]
Open Biology, 2016 The Notch pathway is an essential regulator of cell proliferation and differentiation during development. Its involvement in insect oogenesis has been examined in insect species with meroistic ovaries, and it is known to play a fundamental role in cell ...
Paula Irles +2 more
doaj +1 more source
Advanced Science, EarlyView.This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu +9 more
wiley +1 more source