Results 41 to 50 of about 207,765 (300)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
BMC Plant BiologyBackground Mungbean is one of the most economically important grain legume crops in Asia. Functional genomics studies in mungbean are necessary to understand the molecular mechanisms behind agronomic traits, to advance the crop improvement. However, this
Sanjeev Kumar +3 more
doaj +1 more source
When an Intruder Comes Home: GM and GE Strategies to Combat Virus Infection in Plants
AgricultureViruses are silent enemies that intrude and take control of the plant cell’s machinery for their own multiplication. Infection by viruses and the resulting damage is still a major challenge in the agriculture sector.
Adeeb Rahman, Neeti Sanan-Mishra
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Advancements in biotechnology for enhancing fruit quality and nutritional value: A review [PDF]
Journal of Horticulture and Postharvest ResearchPurpose: Fruit species are essential for nutritional and health security, rich in micronutrients, antioxidants, and bioactive compounds. Recognized as functional foods, they meet current and future dietary requirements.
Muhammad Muhammad +2 more
doaj +1 more source
Current efforts in the analysis of RNAi and RNAi target genes [PDF]
Briefings in Bioinformatics, 2005 RNAi is RNA interference by short RNAs. It influences gene-expression by down-regulation of mRNAs, typically by complementarity to the 3' UTR (untranslated region) of the mRNA. microRNAs (miRNAs) are short RNAs acting as natural RNAi. miRNAs mediate down-regulation of many mRNAs from developmental genes and transcription factor genes.
Peter Bengert, Thomas Dandekar
openaire +2 more sources
Pde1c mutation or Gyc88E overexpression suppresses w-RNAi-induced delay of locomotor recovery.
, 2017 (A) RNAi knockdown of w in serotonin subset delayed locomotor recovery from anoxia. * P 13, 45]. (B) Time to recovery analysis in CS and w1118; Pde1cKG05572/+ flies. There was no significant difference of time to recovery between flies.
Chengfeng Xiao (192558) +1 more
core +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Design of RNAi reagents for invertebrate model organisms and human disease vectors [PDF]
, 2011 RNAi has become an important tool to silence gene expression in a variety of organisms, in particular when classical genetic methods are missing. However, application of this method in functional studies has raised new challenges in the design of RNAi ...
Thomas Horn, Michael Boutros
core
, 2019 Data from Empty Split-GAl4 x UAS Toy-RNAi flies. Figure 8A, Fig. 8 Supplement.
Warren, Timothy L +5 more
core +1 more source