RNAi in Clinical Studies [PDF]
Current Medicinal Chemistry, 2013 RNA interference (RNAi) is an efficient process of posttranscriptional gene silencing. In recent years it has been developed into a new technology in biopharmaceutical fields of science. RNAi products include short interference RNA (siRNA) but also short hairpin RNA (shRNA), bifunctional short hairpin RNA (bi-shRNA) and microRNA (miRNA).
Kubowicz, P. +2 more
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Next-generation 9216-microwell cell arrays for high-content screening microscopy
BioTechniques, 2009 Reverse transfection on cell arrays is a high-throughput method for the parallel transfection of mammalian cells for use in high-content screening light microscopy.
Jürgen Reymann +5 more
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Mapping the Salt Stress-Induced Changes in the Root miRNome in Pokkali Rice
Biomolecules, 2020 A plant’s response to stress conditions is governed by intricately coordinated gene expression. The microRNAs (miRs) have emerged as relatively new players in the genetic network, regulating gene expression at the transcriptional and post ...
Kavita Goswami +4 more
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Frontiers in RNAi: Volume 1 [PDF]
, 2014 RNA interference (RNAi) is a biological process in which small nucleotide sequences destroy specific mRNA molecules and, therefore, interrupt genetic expression.
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Identification and functional analysis of a testis‑biased gene encoding serine/arginine‑rich protein in silkworm, Bombyx mori [PDF]
Archives of Biological Sciences, 2019 Spermatogenesis is a fundamental process in sexual reproduction. In this study, we cloned a 716-bp cDNA of a testis-biased gene in Bombyx mori, named as BmRS-TS, which encodes a polypeptide of 164 amino acids, containing 26.7% arginine and serine ...
Zhang Li-Ying, Li Juan, Zha Xing-Fu
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Evidence of a tick RNAi pathway by comparative genomics and reverse genetics screen of targets with known loss-of-function phenotypes in Drosophila [PDF]
, 2009 Background The Arthropods are a diverse group of organisms including Chelicerata (ticks, mites, spiders), Crustacea (crabs, shrimps), and Insecta (flies, mosquitoes, beetles, silkworm).
Rodriguez Valle, Manuel +35 more
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Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]
, 2013 RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, M. +8 more
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RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs
Cells, 2020 The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in 1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was United States Food and Drug Administration (FDA) approved. This promises to
Sarah Bajan, Gyorgy Hutvagner
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Guangdong nongye kexue, 2023 【Objective】The resistance of Plutella xylostella to chemical insecticides is increasing year by year, which makes RNAi (RNA interference) pesticides widely concerned. The P.
Jianbin TAN +3 more
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Fission yeast Dicer harbours a unique dsRBD that participates in the spatial organization of the RNAi pathway [PDF]
, 2011 The term RNAi describes a set of conserved pathways found in most eukaryotes. RNAi is involved in various cellular processes, ranging from the control of gene expression to the establishment of heterochromatic structures.
Emmerth, Stephan
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