Results 11 to 20 of about 147,575 (261)
Bacterial Delivery of RNAi Effectors: Transkingdom RNAi [PDF]
Journal of Visualized Experiments, 2010 RNA interference (RNAi) represents a high effective mechanism for specific inhibition of mRNA expression. Besides its potential as a powerful laboratory tool, the RNAi pathway appears to be promising for therapeutic utilization. For development of RNA interference (RNAi)-based therapies, delivery of RNAi-mediating agents to target cells is one of the ...
Lage, Hermann, Krühn, Andrea
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Asian Citrus Psyllid RNAi Pathway – RNAi evidence [PDF]
Scientific Reports, 2016 AbstractDiaphorina citri, known as the Asian citrus psyllid, is an important pest of citrus because it transmits a phloem-limited bacteria strongly implicated in huanglongbing (citrus greening disease). Emerging biotechnologies, such as RNA interference, could provide a new sustainable and environmentally friendly strategy for the management of this ...
Taning, Nji Tizi Clauvis +4 more
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RNAi in Clinical Studies [PDF]
Current Medicinal Chemistry, 2013 RNA interference (RNAi) is an efficient process of posttranscriptional gene silencing. In recent years it has been developed into a new technology in biopharmaceutical fields of science. RNAi products include short interference RNA (siRNA) but also short hairpin RNA (shRNA), bifunctional short hairpin RNA (bi-shRNA) and microRNA (miRNA).
P, Kubowicz, D, Żelaszczyk, E, Pękala
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RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs
Cells, 2020 The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in 1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was United States Food and Drug Administration (FDA) approved. This promises to
Sarah Bajan, Gyorgy Hutvagner
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Molecular Therapy, 2011 A recurring theme in the way that many pharmaceutical companies approach new technologies is that they are initially extremely enthusiastic, perhaps excessively so, but then subsequently overreact in the opposite direction, abandoning them when the first bumps in the road come along.
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Developmental Cell, 2005 Processing bodies (P bodies) are discrete cytoplasmic foci to which mRNA is routed for degradation. In mammalian cells, they are also associated with miRNA-induced translational silencing and siRNA-induced mRNA degradation. In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting protein that appears to promote the ...
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Argonaute 2 Is Required for Extra-embryonic Endoderm Differentiation of Mouse Embryonic Stem Cells
Stem Cell Reports, 2018 Summary: In mouse, although four Argonaute (AGO) proteins with partly overlapping functions in small-RNA pathways exist, only Ago2 deficiency causes embryonic lethality.
Richard Patryk Ngondo +10 more
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RNAi Mechanisms and Applications
BioTechniques, 2008 (Uploaded by Plazi for the IPBES Invasive Alien Species Assessment) No abstract provided.
Daniel H. Kim, John J. Rossi
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Comparative miRomics of Salt-Tolerant and Salt-Sensitive Rice
Journal of Integrative Bioinformatics, 2017 Increase in soil salt causes osmotic and ionic stress to plants, which inhibits their growth and productivity. Rice production is also hampered by salinity and the effect of salt is most severe at the seedling and reproductive stages. Salainity tolerance
Goswami Kavita +2 more
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European Journal of Entomology, 2017 RNA interference (RNAi) technology uses dsRNAs to silence specific targeted genes by downregulating their expression. It has become a potent tool for functional and regulatory studies of insect genes and has potential to be applied for insect control ...
Saikat Kumar B. GHOSH +1 more
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