Results 71 to 80 of about 198,612 (296)
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Insects, 2019 Clip domain serine proteases play vital roles in various innate immune functions and in embryonic development. Nilaparvata lugens proclotting enzymes (NlPCEs) belong to this protease family.
Jia-min Wu +5 more
doaj +1 more source
RNAi-Mediated Silencing of ITPK Gene Reduces Phytic Acid Content
, 2019 Revision of RNAi-Mediated Silencing of ITPK Gene Reduces Phytic Acid ...
Swapan Datta (7021088)
core +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
RNAi and antiviral defense in Drosophila: Setting up a systemic immune response [PDF]
, 2014 RNA interference (RNAi) controls gene expression in eukaryotic cells and thus, cellular homeostasis. In addition, in plants, nematodes and arthropods it is a central antiviral effector mechanism.
Saleh, Maria-Carla +4 more
core +1 more source
ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function
FEBS Open Bio, EarlyView.Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
Effects of silencing APN gene on proliferation, invasion and apoptosis of human glioma U251 cells
Di-san junyi daxue xuebao, 2020 Objective To determine the effect of aminopeptidase N (APN) on the proliferation, invasion, and apoptosis in human glioma U251 cells and to investigate the possible mechanism.
DONG Yunpeng, CHENG Yuan, CHEN Jin
doaj +1 more source
RNAi-mediated depletion of Rcd1, Rcd5, MBD-R2 or Wds disrupts chromosome segregation.
, 2019 (A-B) Mitotic figures observed in mock-treated control cells (A), and in Rcd1, Rcd5 or MBD-R2 RNAi cells (B) stained for DNA (blue), α-tubulin (green) and Cyclin B (CycB; red).
Anastasiya L. Oshchepkova (7392689) +11 more
core +1 more source