Results 91 to 100 of about 198,612 (296)

RNA interference targets arbovirus replication in Culicoides cells [PDF]

, 2013
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana, Esther Schnettler, Ratinier, Maxime, Shaw, Andrew, Palmarini, Massimo, Kohl, Alain, Mariana Varela, Mick Watson, Elliott, Richard M., Alain Kohl, Maxime Ratinier, McFarlane, Melanie, Shaw, Andrew E., Elliott, Richard, Richard M, Massimo Palmarini, Schnettler, Esther, E. Shaw, Watson, Mick, A Alain Kohla, Melanie Mcfarlane   +20 more
core   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Hairpin in a haystack: In silico identification and characterization of plant-conserved microRNA in Rafflesiaceae

Open Life Sciences
Rafflesiaceae is a family of endangered plants whose members are solely parasitic to the tropical grape vine Tetrastigma (Vitaceae). Currently, the genetics of their crosstalk with the host remains unexplored.
Wicaksono Adhityo, Meitha Karlia, Wan Kiew-Lian, Mat Isa Mohd Noor, Parikesit Arli Aditya, Molina Jeanmaire   +5 more
doaj   +1 more source

Visualization and Quantification of Transposon Activity in Caenorhabditis elegans RNAi Pathway Mutants

G3: Genes, Genomes, Genetics, 2019
RNA silencing pathways play critical roles in maintaining quiescence of transposons in germ cells to promote genome integrity. However the precise mechanism by which different types of transposons are recognized by these pathways is not fully understood.
Dylan C. Wallis, Dieu An H. Nguyen, Celja J. Uebel, Carolyn M. Phillips   +3 more
doaj   +1 more source

Pde1c mutation or Gyc88E overexpression suppresses w-RNAi-induced delay of locomotor recovery.

, 2017
(A) RNAi knockdown of w in serotonin subset delayed locomotor recovery from anoxia. * P 13, 45]. (B) Time to recovery analysis in CS and w1118; Pde1cKG05572/+ flies. There was no significant difference of time to recovery between flies.
Chengfeng Xiao (192558), R. Meldrum Robertson (37544)   +1 more
core   +1 more source

The RNA Polymerase II-associated factor 1 complex represses small-RNA-mediated heterochromatin formation and gene silencing [PDF]

, 2015
RNAi interference (RNAi) is a highly conserved regulatory mechanism employed by almost all Eukaryotes. With RNAi organisms can modulate the expression of endogenous genes and protect the integrity and identity of their genomes.
Kowalik, Katarzyna Maria
core   +1 more source

RNAi-mediated resistance to SMV and BYMV in transgenic tobacco

, 2016
Soybean mosaic virus (SMV) and bean yellow mosaic virus (BYMV) are two typical types of viruses that cause mosaic in soybean plants. Multiple viral infections at the same site can lead to 66% to 80% yield reduction.
Lo Thi Mai Thu (12845396), Chu Hoang Ha (12845408), Le Van Son (12845405), Le Hoang Duc (12845402), Vi Thi Xuan Thuy (12845399), Chu Hoang Mau (12845411)   +5 more
core   +1 more source

Targeted Delivery of Indole‐3‐Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8+ T Cell‐Mediated Immunotherapy Response in Bladder Cancer

Advanced Science, EarlyView.
A microbiota‐derived metabolite, indole‐3‐pyruvic acid, suppresses macrophage ferroptosis through the AHR–NF‐κB–SLC7A11 axis. This preserves CD8+ T cell function in bladder cancer. Macrophage‐targeted nanoparticles enhance indole‐3‐pyruvic acid delivery and overcome resistance to PD‐1 blockade.
Jianwen Lao, Xinhao Yuan, Shuai Liang, Kai Deng, Daqin Wu, Longhao Xu, Kun Zheng, Yi Lin, Peicong Cai, Haoran Zheng, Junyu Chen, Mingli Luo, Yan Chen, Xiong Chen, Chunhui Wang, Wenlong Zhong   +15 more
wiley   +1 more source

Advanced Techniques to Control Mosquitoes and their Disease Transmission: A Review

Journal of Pure and Applied Microbiology
Mosquitoes transmit life-threatening diseases to humans. The conventional mosquito control techniques that have been focused on population reduction by the application of insecticides or through source reduction by removing the larval habitat have become
S. Renuka
doaj   +1 more source

ss00096 x UAS-Toy-RNAi

, 2019
Data from ss00096 Split-Gal4 x UAS Toy-RNAi flies. Figure 8b, Figure 8 Supplement.
Warren, Timothy L, Sullivan, Luis F, Timothy L Warren (8027468), Doe, Chris Q, Chris Q Doe (4916230), Luis F Sullivan (8027471)   +5 more
core   +1 more source