Results 91 to 100 of about 207,765 (300)

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

RNAi-Mediated Management of Whitefly Bemisia tabaci by Oral Delivery of Double-stranded RNAs

Proceedings, 2019
The whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae) is a significant global pest of economically important vegetable, fibre, and ornamental crops. Whiteflies directly damage the plants by piercing and sucking essential nutrients, indirectly through ...
Ritesh G Jain, Karl Robinson, Neena Mitter   +2 more
doaj   +1 more source

List of siRNA and dsRNA targets for Laccase gene by ERNAi (Boutros lab, E-RNAi-Version 3.2; Horn and Boutros 2010) (On page 7 before discussion).

, 2023
List of siRNA and dsRNA targets for Laccase gene by ERNAi (Boutros lab, E-RNAi-Version 3.2; Horn and Boutros 2010) (On page 7 before discussion).
Muhammad Azmat Ullah Khan (10746097), Nadia Zeeshan (6093272), Amber Afroz (15447539), Asma Rafique (15447536), Nazia Rehman (12992910), Umer Rashid (2883806), Muhammad Irfan (255476), Waheed Chatha (15447542), Muhammad Ramzan Khan (12101716)   +8 more
core   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Speeding up RNAi [PDF]

Nature Methods, 2011
A recent study turns the creation of conditional short hairpin RNA transgenic mice into a rapid, flexible and scalable process.
openaire   +2 more sources

RNAi-mediated loss-of-function phenotypes of the sex determination genes.

, 2019
(A) Representative individuals in each RNAi treatment in males (the left half) and females (the right half). Each dsRNA was injected into last-instar larvae. The negative control RNAi treatment (EGFP dsRNA) showed no morphological defects. The upper row,
Teruyuki Niimi (120428), Toshiya Ando (4799187), Mutsuki Mase (5818940), Shuji Shigenobu (464699), Akiteru Maeno (4380283), Takeshi Mizutani (1584310), Shinichi Morita (592221)   +6 more
core   +1 more source

Distinct Cleavage Trajectories Mediated by DNA and RNA Substrate in Argonaute From Methanocaldococcus Fervens

Advanced Science, EarlyView.
This study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Fuyong Huang, Taiyu Chen, Meng Fang, Qinmiao Duanmu, Kangle Mu, Yuqi Bi, Siwei Xu, Xin Tao, Jiening Wang, Shan Wu   +9 more
wiley   +1 more source

Elucidating the Pathogenic Mechanism of Spinal Muscular Atrophy Through the Investigation of UTS2

Frontiers in Bioscience-Landmark
Background: Spinal muscular atrophy (SMA) is a severe neuromuscular disorder caused by mutations in the survival motor neuron 1 (SMN1) gene, resulting in progressive motor neuron loss and muscle atrophy.
Xu Zhang, Liqi Yang
doaj   +1 more source

Preparation Optimization of Bovine Serum Albumin Nanoparticles and Its Application for siRNA Delivery

Drug Design, Development and Therapy, 2021
Yifan Wang,1– 3 Si Chen,1– 3 Xin Yang,1– 3 Shuang Zhang,1– 3 Chunying Cui1– 3 1Department of Pharmaceutics, School of Pharmaceutical Sciences, Capital Medical University, Beijing, People’s Republic of China ...
Wang Y, Chen S, Yang X, Zhang S, Cui C
doaj  

RNA interference targets arbovirus replication in Culicoides cells [PDF]

, 2013
Arboviruses are transmitted to vertebrate hosts by biting arthropod vectors such as mosquitoes, ticks and midges. These viruses replicate in both arthropods and vertebrates and are thus exposed to different antiviral responses in these organisms.
Varela, Mariana, Esther Schnettler, Ratinier, Maxime, Shaw, Andrew, Palmarini, Massimo, Kohl, Alain, Mariana Varela, Mick Watson, Elliott, Richard M., Alain Kohl, Maxime Ratinier, McFarlane, Melanie, Shaw, Andrew E., Elliott, Richard, Richard M, Massimo Palmarini, Schnettler, Esther, E. Shaw, Watson, Mick, A Alain Kohla, Melanie Mcfarlane   +20 more
core   +1 more source