Results 101 to 110 of about 207,765 (300)
Advanced Science, EarlyView.The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng +10 more
wiley +1 more source
Entwicklung und Etablierung von induzierbaren RNAi-Systemen zur Regulierung der Expression von Polo-like Kinase 1 (Plk1) in vitro und in vivo [PDF]
, 2007 RNA-Interferenz (RNAi) erlangte eine herausragende Bedeutung zum Studium der Genfunktion, nachdem auch in Säugersystemen gezeigt wurde, daß durch Applikation von 21 nt langen siRNAs (small interfering RNAs) eine Sequenz-spezifische Degradierung der mRNA ...
Kappel, Sven
core
Sildenafil feeding suppresses w-RNAi-induced delay of locomotor recovery.
, 2017 (A) Time to recovery in flies (w+;; R50E11-Gal4/UAS-w-RNAi) fed with food containing 0, 1, 10 or 100 μM sildenafil. * P μM sildenafil). Flies were fed for 4 days after eclosion. * P μM sildenafil. Feeding duration was the same as B.
Chengfeng Xiao (192558) +1 more
core +1 more source
Chromosome-wide analysis of gene function by RNA interference in the african trypanosome. [PDF]
, 2006 Trypanosomatids of the order Kinetoplastida are major contributors to global disease and morbidity, and understanding their basic biology coupled with the development of new drug targets represents a critical need.
J. Hayes-Sinclair +23 more
core +1 more source
Advanced Science, EarlyView.CYYR1 as an epigenetically dysregulated tumor‐suppressive factor that influences oncoprotein stability through TRIM21‐dependent HMMR regulation and reveals a potential therapeutic vulnerability in CYYR1‐deficient LUAD. The graphical illustration was created using FigDraw (www.figdraw.com).
Fengsheng Dai +15 more
wiley +1 more source
, 2019 (A) RNAi efficiency and (B) PKA activity after transcript knockdown of the catalytic C1 subunit of PKA encoding gene (pkac1). Effects on (C) p-CREB-B and (D) NOS transcription levels after the transcript knockdown of pkac1 in G-phase locusts.
Xianhui Wang (153325) +4 more
core +1 more source
Advanced Science, EarlyView.Hypertrophic scar fibroblasts membrane‐hybridized cationic transfersomes enable efficient loading and transdermal delivery of TGF‐β1 siRNA through multiple skin penetration pathways. The biomimetic platform enhances homotypic targeting, transfection, and immune evasion, suppresses TGF‐β1‐driven fibrotic signaling, and reduces extracellular matrix ...
Hui Xing +9 more
wiley +1 more source
Insects, 2019 Clip domain serine proteases play vital roles in various innate immune functions and in embryonic development. Nilaparvata lugens proclotting enzymes (NlPCEs) belong to this protease family.
Jia-min Wu +5 more
doaj +1 more source
, 2023 RNA interference (RNAi)-mediated control of the notorious pest Henosepilachna vigintioctopunctata is an emerging environment friendly research area. However, the characterization of key target genes in H.
Shimin Chen (5368544) +15 more
core +1 more source
Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice
Advanced Science, EarlyView.CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu +8 more
wiley +1 more source