Results 101 to 110 of about 198,612 (296)
Advanced Science, EarlyView.Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu +9 more
wiley +1 more source
RNAi-mediated loss-of-function phenotypes of the sex determination genes.
, 2019 (A) Representative individuals in each RNAi treatment in males (the left half) and females (the right half). Each dsRNA was injected into last-instar larvae. The negative control RNAi treatment (EGFP dsRNA) showed no morphological defects. The upper row,
Teruyuki Niimi (120428) +6 more
core +1 more source
Advanced Science, EarlyView.In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu +16 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2019 Physiology, fitness and disease phenotypes are complex traits exhibiting continuous variation in natural populations. To understand complex trait gene functions transgenic lines of undefined genetic background are often combined to assess quantitative ...
Amalia Evangelou +10 more
doaj +1 more source
Advanced Science, EarlyView.Single‐cell transcriptomics of soybean roots soon after rhizobial inoculation reveals epidermal and cortical cell‐specific programs and gene‐regulatory networks acting in symbiosis establishment. We identify an ethylene‐driven regulatory circuit involving WRKY6.3/6.4 transcription factors targeting select Nod19 genes that promotes infection‐thread ...
Yongbin Zhuang +17 more
wiley +1 more source
, 2019 (A) RNAi efficiency and (B) PKA activity after transcript knockdown of the catalytic C1 subunit of PKA encoding gene (pkac1). Effects on (C) p-CREB-B and (D) NOS transcription levels after the transcript knockdown of pkac1 in G-phase locusts.
Xianhui Wang (153325) +4 more
core +1 more source
Meeting review : ESF workshop on "Impact of nucleic acid chemistry on gene function analysis: antisense, aptamers, ribozymes and RNAi" [PDF]
, 2008 The shortage of functional information compared to the abundance of sequence information characterizes today’s situation in functional genomics. For many years the knock-down of a gene’s product has been the most powerful way of analysing its function ...
Prydz, Hans +3 more
core +1 more source
Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment
Advanced Science, EarlyView.This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo +15 more
wiley +1 more source
Molecular Cell, 2003 RNA interference (RNAi) describes the ability of double-stranded RNA (dsRNA) to inhibit homologous gene expression at the RNA or DNA level. In a recent paper, Feinberg and Hunter report that a single transmembrane dsRNA transport protein may enable RNAi to spread systemically from one cell to another.
openaire +2 more sources
RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance [PDF]
, 2011 The ribosome-inhibiting toxin ricin binds exposed β1→4 linked galactosyls on multiple glycolipids and glycoproteins on the cell surface of most eukaryotic cells. After endocytosis, internal cell trafficking is promiscuous, with only a small proportion of
Omar, Mahmoud M. +17 more
core +1 more source