Results 111 to 120 of about 198,612 (296)
Advanced Science, EarlyView.This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li +15 more
wiley +1 more source
Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells
Molecular & Cellular Oncology, 2019 A genome-wide small-interfering RNA-based screen identified the transcription factor Specificity Protein 3 (SP3) as a critical factor for Second mitochondrial-derived activator of caspase (Smac) mimetic-mediated killing of cancer cells.
Shawn T. Beug +2 more
doaj +1 more source
Nature Methods, 2011 A recent study turns the creation of conditional short hairpin RNA transgenic mice into a rapid, flexible and scalable process.
openaire +2 more sources
RNAi-mediated knockdown of daf-12 in the model parasitic nematode Strongyloides ratti
, 2019 The gene daf-12 has long shown to be involved in the dauer pathway in Caenorhabditis elegans (C. elegans). Due to the similarities of the dauer larvae of C. elegans and infective larvae of certain parasitic nematodes such as Strongyloides spp., this gene
Alex Dulovic (6528617) +1 more
core +1 more source
Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia
Advanced Science, EarlyView.Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li +8 more
wiley +1 more source
Development of a SCA7 patient-derived lymphoblast cell model for testing RNAi knock-down of the disease-causing gene [PDF]
, 2011 Includes bibliographical references (leaves 106-116).Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease caused by the expansion of a CAG repeat within the ataxin-7 gene. The South African SCA7 population has been shown to have
Berkowitz, Danielle Claire
core +1 more source
Biologia Plantarum, 2019 Sri Lankan cassava mosaic virus (SLCMV) is the principal causal agent of cassava mosaic disease in the Indian subcontinent. To gain resistance against the virus, the coat protein (CP) gene, namely the AV1 of SLCMV-Adivaram isolate, was cloned in either ...
A. GOGOI +4 more
doaj +1 more source
Advanced Science, EarlyView.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon +6 more
wiley +1 more source
RNAi-mediated SIFa knockdown weakens feeding:fasting and rest:activity rhythms.
, 2019 (A) Representative maximum projection confocal images of SIFa antibody staining showing a closeup of the PI region of the brain for the indicated genotypes.
Carson V. Fulgham (7828118) +6 more
core +1 more source
A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans. [PDF]
, 2011 One of the central goals of developmental neurobiology is to describe and understand the multi-tiered molecular events that control the progression of a fertilized egg to a terminally differentiated neuron.
Poole Richard J. +16 more
core +1 more source