Results 91 to 100 of about 430,076 (284)

Decrease in gyrase A protein expression in _E. coli_ cells inhibited by antisense ribozymes [PDF]

, 2008
RNase P complexed with external guide sequence (EGS) represents a novel nucleic-acid-based gene interference approach to modulate gene expression. Nucleic acid-based gene interference technologies represent promising strategies for specific inhibition of
Malathi Raghunathan, Shilpakala Sainath Rao   +1 more
core   +1 more source

Elucidating the Structure and Regulatory Interactions of the HOTAIR Non-Coding RNA and the Bacterial RNase P. Holoenzyme [PDF]

, 2023
RNA structures and RNA-protein interactions are studied as potential drug targets, biomarkers in cancer, and can be administered as vaccines. The cancer associated HOTAIR (HOX transcript antisense RNA) exists in higher vertebrates and interacts with ...
Abzhanova, Ainur
core   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Synergies between RNA degradation and trans-translation in Streptococcus pneumoniae: cross regulation and co-transcription of RNase R and SmpB

BMC Microbiology, 2012
Background Ribonuclease R (RNase R) is an exoribonuclease that recognizes and degrades a wide range of RNA molecules. It is a stress-induced protein shown to be important for the establishment of virulence in several pathogenic bacteria. RNase R has also
Moreira Ricardo N, Domingues Susana, Viegas Sandra C, Amblar Mónica, Arraiano Cecília M   +4 more
doaj   +1 more source

Magnetite Nanoparticles Functionalized with RNases against Intracellular Infection of Pseudomonas aeruginosa

Pharmaceutics, 2020
Current treatments against bacterial infections have severe limitations, mainly due to the emergence of resistance to conventional antibiotics. In the specific case of Pseudomonas aeruginosa strains, they have shown a number of resistance mechanisms to ...
Nathaly Rangel-Muñoz, Alejandra Suarez-Arnedo, Raúl Anguita, Guillem Prats-Ejarque, Johann F. Osma, Carolina Muñoz-Camargo, Ester Boix, Juan C. Cruz, Vivian A. Salazar   +8 more
doaj   +1 more source

Viperin mRNA is a novel target for the human RNase MRP/RNase P endoribonuclease [PDF]

, 2010
RNase MRP is a conserved endoribonuclease, in humans consisting of a 267-nucleotide RNA associated with 7–10 proteins. Mutations in its RNA component lead to several autosomal recessive skeletal dysplasias, including cartilage-hair hypoplasia (CHH ...
A Roth, Bernhard Zabel, Carla Onnekink, CT Thiel, CT Thiel, D Jiang, DD Chang, Ella R. Hinson, ER Hinson, ER Hinson, FD Kavadas, G Krupp, G Schilders, Ger J. M. Pruijn, H Eenennaam Van, H Pluk, H Wu, HD Robertson, I Sanchez, JS Andersen, KC Chin, L Lindahl, LD Notarangelo, LQ Qiu, M Ashburner, M Hata, M Ridanpää, M Taskinen, NL Rider, O Makitie, O Makitie, O Makitie, O Makitie, P Hermanns, P Roepman, Peter Cresswell, Pia Hermanns, R Reiner, R Reiner, S Granneman, S Toiviainen-Salo, Sandy Mattijssen, SC Walker, T Gill, T Gill, TJ Welting, TJ Welting, TJ Welting, TS Grewal, V Baud, VA McKusick, X Wang, Y Maida, YH Yang, YW Lam, Z Lygerou   +55 more
core   +3 more sources

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Purification and Biophysical Study of RNase P Proteins 21 and 29 from Methanocaldococcus jannaschii [PDF]

, 2010
RNase P is an endonuclease with a rare catalytic RNA core. The enzyme is a ribonucleoprotein (RNP) complex and is primarily responsible for cleaving the 5’ RNA leader sequence from precursor tRNA (ptRNA) molecules. The maturation of tRNA is necessary for
Smith, David
core  

EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks [PDF]

, 2019
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA clearance is an essential step in homologous ...
Bonath, Franziska, Domingo Prim, Judit, Endara Coll, Martin, Friedländer, Marc R., Huertas Sánchez, Pablo, Jimeno González, Sonia, Prados Carvajal, Rosario, Visa, Neus   +7 more
core   +2 more sources