Results 91 to 100 of about 25,923,055 (288)

microRNA‐7‐5p and α‐Synuclein SAA Predict Parkinson's Disease Phenoconversion

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Shayan Zadegan, Praveen Velammal, Kanmani Muthiah, Madhu Jatty, Christopher Adams   +4 more
wiley   +1 more source

Identification of RMP24 and RMP64, human ribonuclease MRP-specific protein components

Cell Reports
Summary: Human RNase MRP is a ribonucleoprotein (RNP) enzyme that processes precursor rRNA (pre-rRNA) at ITS1 site 2 and may have additional activities. It is an endonuclease related to RNase P, which processes pre-tRNAs and pre-tRNA-like substrates.
Rui Che, Bhoomi Mirani, Monireh Panah, Xiaotong Chen, Hong Luo, Andrei Alexandrov   +5 more
doaj   +1 more source

Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives

Biomolecules, 2016
There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities.
Shiying Wu, Guanzhong Mao, Leif A. Kirsebom   +2 more
doaj   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Characterization of one new non-S-RNase of Armeniaca cathayana

Czech Journal of Genetics and Plant Breeding, 2019
Armeniaca cathayana, a new species described in 2010, belongs to gametophytic self-incompatibility (GSI) system which is under S-allele control. One new non-S-ribonuclease (non-S-RNase) was found in A. cathayana through comparing its nucleotide and amino
Mengpei Liu, Pei Hou, Xiaoyuan Wang, Yu Dong, Wei Zong   +4 more
doaj   +1 more source

Varieties of RNase P: A nomenclature problem?

RNA, 2000
Twenty-five years ago, a basic tenet of biochemistry held that enzymes are made solely of protein. Ribosomes, which are large ribonucleoprotein enzymes, were conveniently overlooked (but see Woese, 1967; Crick, 1968; Orgel, 1968). The then current orthodoxy was first challenged by the discovery that Escherichia coli RNase P had an essential RNA subunit
S, Altman, V, Gopalan, A, Vioque
openaire   +3 more sources

Membrane recognition and dynamics of the RNA Degradosome [PDF]

, 2015
RNase E, which is the central component of the multienzyme RNA degradosome, serves as a scaffold for interaction with other enzymes involved in mRNA degradation including the DEAD-box RNA helicase RhlB.
Luisi, Ben, Syma Khalid (580907), Bouvier, Marie, Turlan, Catherine, Kebalo, J.M., Peyron, Pascale, Leonora Poljak, Peter J Bond, Peter J. Bond (688987), Strahl, H., Poljak, Leonora, Carpousis, A.J., Khalid, Syma, Ben F. Luisi (688991), Turlan, C., Henrik Strahl, Strahl, Henrik, Syma Khalid, Khalid, S., Jean-Marie Kebalo, Pascale Peyron, Henrik Strahl (688985), Catherine Turlan, Bouvier, M., Marie Bouvier, Agamemnon J. Carpousis (12453), Jean-Marie Kebalo (688988), Agamemnon J Carpousis, Pascale Peyron (239058), Leendert Hamoen (688990), Bond, Peter J., Bond, P.J., Ben F Luisi, Catherine Turlan (688986), Bond, Peter, Viollier, Patrick H., Marie Bouvier (260008), Hamoen, L.; id_orcid, Hamoen, Leendert, Luisi, Ben F., Carpousis, Agamemnon J., Peyron, P., Poljak, L., Luisi, B.F., Kebalo, Jean-Marie, Leendert Hamoen, Leonora Poljak (688989), Carpousis, Agamemnon, Luisi Ben F., Carpousis Agamemnon J., Poljak Leonora, Luisi B.F., Bouvier Marie, Peyron Pascale, Strahl H., Kebalo J.-M., Bouvier M., Bond Peter J., Kebalo Jean-Marie, Poljak L., Khalid Syma, Turlan C., Hamoen L., Carpousis A.J., Bond P.J., Hamoen Leendert, Peyron P., Turlan Catherine, Strahl Henrik, Khalid S.   +69 more
core   +1 more source

Remote Activation of Wnt Signaling and Cell Proliferation by E‐Cadherin Magnetomechanical Stimulation

Advanced Functional Materials, EarlyView.
A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa, Pablo Martínez‐Vicente, Lucía G. Recaredo, Susel Del Sol‐Fernández, Pilar Gomollón‐Zueco, Yilian Fernández‐Afonso, Raluca M. Fratila, María Moros   +7 more
wiley   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding

Retrovirology, 2012
Background The ribonuclease H (RNase H) domains of retroviral reverse transcriptases play an essential role in the replication cycle of retroviruses. During reverse transcription of the viral genomic RNA, an RNA/DNA hybrid is created whose RNA strand ...
Leo Berit, Schweimer Kristian, Rösch Paul, Hartl Maximilian J, Wöhrl Birgitta M   +4 more
doaj   +1 more source