Results 131 to 140 of about 25,923,055 (288)

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Spearman correlations among the RNase P-normalized copy numbers of 5 RSV genes.

, 2017
Spearman correlations among the RNase P-normalized copy numbers of 5 RSV genes.
Reena Mehta (3756193), Letisha Aideyan (3756190), Vasanthi Avadhanula (259546), Pedro A. Piedra (535077), Roberto P. Garofalo (206044), Minghua Mei (3756196), Felipe-Andrés Piedra (3818149)   +6 more
core   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Binding and cleavage of unstructured RNA by nuclear RNase P

, 2011
Ribonuclease P (RNase P) is an essential endoribonuclease for which the best-characterized function is processing the 5′ leader of pre-tRNAs. Compared to bacterial RNase P, which contains a single small protein subunit and a large catalytic RNA subunit ...
Michael C. Marvin, Scott C. Walker, Carol A. Fierke, David R. Engelke   +3 more
core   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

RNase P-normalized RSV gene copy numbers between non-hospitalized and hospitalized infants.

, 2017
RNase P-normalized RSV gene copy numbers between non-hospitalized and hospitalized infants.
Reena Mehta (3756193), Letisha Aideyan (3756190), Vasanthi Avadhanula (259546), Pedro A. Piedra (535077), Roberto P. Garofalo (206044), Minghua Mei (3756196), Felipe-Andrés Piedra (3818149)   +6 more
core   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Pioneering study in the role of Ribonuclease L in the development of gestational diabetes mellitus in pregnant women

Journal of the Formosan Medical Association
Background: Gestational diabetes mellitus as a common pregnancy complication carries metabolic risks for both the mother and infant. We and others have shown that ribonuclease L (RNase-L, an innate immunity regulator) regulates adipogenesis and insulin ...
Yi-Yun Tai, Yi-Ting Wang, Hung-Yuan Li, Hui-Chuen Chen, Chi-Ling Chen, Shin-Yu Lin, Wei-Shiung Yang   +6 more
doaj   +1 more source

Difference between Mitochondrial RNase P and Nuclear RNase P [Letters to the Editor]

, 2001
Copyright © 2001 by the American Society for Microbiology.
Rossmanith, Walter, Potuschak, Thomas, Attardi, Giuseppe, Puranam, Ram S.   +3 more
openaire   +2 more sources

Spearman correlations between RNase P-normalized RSV gene copy numbers and cytokine levels.

, 2017
Spearman correlations between RNase P-normalized RSV gene copy numbers and cytokine levels.
Reena Mehta (3756193), Letisha Aideyan (3756190), Vasanthi Avadhanula (259546), Pedro A. Piedra (535077), Roberto P. Garofalo (206044), Minghua Mei (3756196), Felipe-Andrés Piedra (3818149)   +6 more
core   +1 more source