Results 151 to 160 of about 20,593,893 (291)

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Structural basis for protein-free catalysis by ribonuclease P ribozyme

Nature Communications
Ribonuclease P (RNase P) is an essential metallonuclease found in all three domains of life. However, the structural basis for the ancient RNase P RNA component acting alone as a ribozyme and catalytic metal-ion chemistry remains unknown.
Yun-Tzai Lee, Maximilia F. S. Degenhardt, Ilias Skeparnias, Szu-Yun Chen, Bapurao A. Bhoge, Sergey G. Tarasov, Marzena A. Dyba, Jinwei Zhang, Jason R. Stagno, Yun-Xing Wang   +9 more
doaj   +1 more source

Eukaryotic RNase P [PDF]

Molecular Cell, 2003
Mann, Hagit, Ben-Asouli, Yitzhak, Schein, Aleks, Moussa, Sana, Jarrous, Nayef   +4 more
openaire   +1 more source

RNase MRP RNA and RNase P activity in plants are associated with a Pop1p containing complex

, 2012
RNase P processes the 5'-end of tRNAs. An essential catalytic RNA has been demonstrated in Bacteria, Archaea and the nuclei of most eukaryotes; an organism-specific number of proteins complement the holoenzyme.
Menzel, Nicolas, Seibel, Peter, Heubeck, Christian, Schön, Astrid, Krehan, Mario   +4 more
core   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Human RNase P exhibits and controls distinct ribonucleolytic activities required for ordered maturation of tRNA. [PDF]

Proc Natl Acad Sci U S A, 2023
Orlovetskie N, Mani D, Rouvinski A, Jarrous N.   +3 more
europepmc   +1 more source

PRORP proteins support RNase P activity in both organelles and the nucleus in Arabidopsis

RNase P is an essential enzyme that cleaves the 5′ leader sequence of tRNA precursors. RNase Ps were believed until now to occur universally as ribonucleoproteins in organisms performing RNase P activity.
Gutmann, B. (Bernard), Gobert, A. (Anthony), Giegé, P. (Philippe)   +2 more
core   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Suppressing Kaposi's Sarcoma-Associated Herpesvirus Lytic Gene Expression and Replication by RNase P Ribozyme. [PDF]

Molecules, 2023
Liu Y, Chen YC, Yan B, Liu F.
europepmc   +1 more source

Levels of putative non-tRNA RNase P-substrates in RNase P-swapped yeast strains.

, 2014
RNA was prepared from three independent clonal isolates of BY4743 and its RNase P-swapped derivatives. Precursor RNAs that were previously reported to accumulate in a conditional RNase P-deficiency model [20], [21] were analyzed by quantitative RT-PCR ...
Roland K. Hartmann (8016), Walter Rossmanith (222672), Christoph Weber (610836), Andreas Hartig (6440)   +3 more
core   +1 more source