Results 161 to 170 of about 436,820 (281)

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
Midkine (MDK) is a mediator of the interaction between pancreatic cancer and beta cells. MDK, which originated from pancreatic ductal adenocarcinoma cells, exerted deleterious effects on paraneoplastic beta cells by binding to the SDC4 receptor on the beta cell surface and subsequently downregulating the Ras signaling pathway, thereby impairing insulin
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
wiley   +1 more source

Elucidation of structure-function relationships in Methanocaldococcus jannaschii RNase P, a multi-subunit catalytic ribonucleoprotein. [PDF]

Nucleic Acids Res, 2022
Phan HD, Norris AS, Du C, Stachowski K, Khairunisa BH, Sidharthan V, Mukhopadhyay B, Foster MP, Wysocki VH, Gopalan V.   +9 more
europepmc   +1 more source

Processing of transcription products of the gene encoding the RNA component of RNase P.

, 1983
Hiroshi Sakamoto, Narimichi Kimura, Y. Shimura   +2 more
openalex   +1 more source

Successful transformation of yeast mitochondria withRPM1: an approach forin vivostudies of mitochondrial RNase P RNA structure, function and biosynthesis [PDF]

, 1995
Pavol Sulo, Kathleen R. Groom, Carol A. Wise, Marlene C. Steffen, Nancy Martín   +4 more
openalex   +1 more source

LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing

Advanced Science, EarlyView.
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang, Yuehui Xi, Qiaojun Fang, Sai Shi, Fei Wang, Fuyu Xian, Zhongyang Zhang, Yuxin Yang, Xishuo Jin, Xiaomin Wang, Chen Cao, Hailin Zhang, Nikita Gamper, Zhigang Xu, Haitao Shen, Ping Lv   +15 more
wiley   +1 more source

RNase P Inhibitors Identified as Aggregators. [PDF]

Antimicrob Agents Chemother, 2021
Schencking I, Schäfer EM, Scanlan JHW, Wenzel BM, Emmerich RE, Steinmetzer T, Diederich WE, Schlitzer M, Hartmann RK.   +8 more
europepmc   +1 more source

In vitro analysis of processing at the 3'-end of precursors of M1 RNA, the catalytic subunit of Escherichia coli RNase P: Multiple pathways and steps for the processing [PDF]

, 1999
Semi Kim, Soyeong Sim, Younghoon Lee
openalex   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

The Dynamic Network of RNP RNase P Subunits. [PDF]

Int J Mol Sci, 2021
Shaukat AN, Kaliatsi EG, Skeparnias I, Stathopoulos C.   +3 more
europepmc   +1 more source

Determinants ofEscherichia coilRNase P cleavage site selection: a detailedin vitroandin vivoanalysis

, 1993
Staffan G. Svärd, Leif A. Kirsebom
openalex   +2 more sources