Results 211 to 220 of about 20,593,893 (291)

The rice RNase P protein subunit Rpp30 confers broad-spectrum resistance to fungal and bacterial pathogens. [PDF]

Plant Biotechnol J, 2021
Li W, Xiong Y, Lai LB, Zhang K, Li Z, Kang H, Dai L, Gopalan V, Wang GL, Liu W.   +9 more
europepmc   +1 more source

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

RNase P cleavage of pseudoknot substrates reveals differences in active site architecture that depend on residue N-1 in the 5' leader. [PDF]

RNA Biol
Kosek DM, Leal JL, Kikovska-Stojanovska E, Mao G, Wu S, Flores SC, Kirsebom LA.   +6 more
europepmc   +1 more source

Minimal protein-only RNase P structure reveals insights into tRNA precursor recognition and catalysis. [PDF]

J Biol Chem, 2021
Teramoto T, Koyasu T, Adachi N, Kawasaki M, Moriya T, Numata T, Senda T, Kakuta Y.   +7 more
europepmc   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P. [PDF]

Nucleic Acids Res
Sidharthan V, Sibley CD, Dunne-Dombrink K, Yang M, Zahurancik WJ, Balaratnam S, Wilburn DB, Schneekloth JS, Gopalan V.   +8 more
europepmc   +1 more source

Protein cofactors and substrate influence Mg2+-dependent structural changes in the catalytic RNA of archaeal RNase P. [PDF]

Nucleic Acids Res, 2021
Marathe IA, Lai SM, Zahurancik WJ, Poirier MG, Wysocki VH, Gopalan V.   +5 more
europepmc   +1 more source

Antisense Inhibition of RNase P [PDF]

Journal of Biological Chemistry, 2006
Heike Gruegelsiepe, Ole Brandt, Roland K. Hartmann   +2 more
openaire   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Surveillance of RNase P, PMMoV, and CrAssphage in wastewater as indicators of human fecal concentration across urban sewer neighborhoods, Kentucky. [PDF]

FEMS Microbes, 2022
Holm RH, Nagarkar M, Yeager RA, Talley D, Chaney AC, Rai JP, Mukherjee A, Rai SN, Bhatnagar A, Smith T.   +9 more
europepmc   +1 more source