Results 281 to 284 of about 430,076 (284)
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2009
The indispensability of RNase P for cell survival and its distinct architecture in Bacteria and Eukarya qualify this ribonucleoprotein enzyme as a potential drug target, although natural inhibitors of bacterial RNase P have not yet been identified. We report on the various attempts pursued so far to explore RNase P as a drug target.
Patrick Pfeffer +4 more
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The indispensability of RNase P for cell survival and its distinct architecture in Bacteria and Eukarya qualify this ribonucleoprotein enzyme as a potential drug target, although natural inhibitors of bacterial RNase P have not yet been identified. We report on the various attempts pursued so far to explore RNase P as a drug target.
Patrick Pfeffer +4 more
openaire +2 more sources
Roles of RNase P and Its Subunits
Trends in Genetics, 2017Recent studies show that nuclear RNase P is linked to chromatin structure and function. Thus, variants of this ribonucleoprotein (RNP) complex bind to chromatin of small noncoding RNA genes; integrate into initiation complexes of RNA polymerase (Pol) III; repress histone H3.3 nucleosome deposition; control tRNA and PIWI-interacting RNA (piRNA) gene ...
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2009
RNase P is an almost universal enzyme present in Bacteria, Archaea and Eukaryotic nuclei, as well as in mitochondria and chloroplasts. The organellar enzyme shows a great variability in structure and composition. A gene encoding an RNA, homologous to bacterial catalytic RNase P RNA, is found in mitochondria of a diversity of organisms that include ...
openaire +2 more sources
RNase P is an almost universal enzyme present in Bacteria, Archaea and Eukaryotic nuclei, as well as in mitochondria and chloroplasts. The organellar enzyme shows a great variability in structure and composition. A gene encoding an RNA, homologous to bacterial catalytic RNase P RNA, is found in mitochondria of a diversity of organisms that include ...
openaire +2 more sources