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RND pumps across the genus Acinetobacter: AdeIJK is the universal efflux pump [PDF]
Microbial Genomics, 2023 Acinetobacter are generally soil-dwelling organisms that can also cause serious human infections. A. baumannii is one of the most common causative agents of Acinetobacter infections and is often multidrug resistant.
Jessica M A Blair +2 more
exaly +4 more sources
Computer simulations of the activity of RND efflux pumps
Research in Microbiology, 2018 The putative mechanism by which bacterial RND-type multidrug efflux pumps recognize and transport their substrates is a complex and fascinating enigma of structural biology.
Venkata Krishnan Ramaswamy +2 more
exaly +6 more sources
RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance
Future Microbiology, 2020 Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore directly contributing to multidrug resistance.
Jessica M A Blair +2 more
exaly +2 more sources
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Reconstitution of the activity of RND efflux pumps: a “bottom-up” approach
Research in Microbiology, 2018Efflux pumps are systems devoted to the extrusion of noxious compounds. In this review, we discuss the various strategies that have thus far been undertaken for the investigation of efflux pumps after reconstitution into liposomes. It is challenging to uncover mechanisms and dynamics of efflux pumps due to a number of characteristics: their function ...
Puvanendran, Dhenesh +2 more
openaire +3 more sources
Screening of Natural Products and Derivatives for the Identification of RND Efflux Pump Inhibitors
Combinatorial Chemistry & High Throughput Screening, 2016Overexpression of efflux pumps belonging to the Resistance Nodulation cell Division (RND) family is the most important intrinsic resistance mechanism of Pseudomonas aeruginosa. Hence, it is imperative to identify suitable efflux pump inhibitors (EPI) that can lead to increased intracellular concentration of antibiotics by blocking the pump.
Debarati, Choudhury +4 more
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The pseudo-atomic structure of an RND-type tripartite multidrug efflux pump
Biological Chemistry, 2015Abstract Microorganisms encode several classes of transmembrane molecular pumps that can expel a wide range of chemically distinct toxic substances. These machines contribute to the capacity of the organisms to withstand harsh environments, and they help to confer resistance against clinical antimicrobial agents.
Dijun, Du +4 more
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Structures and Transport Mechanisms of RND Efflux Pumps
2016Multidrug efflux transporters of the resistance-nodulation-cell division (RND) superfamily are one of the main causes of multidrug resistance (MDR) in Gram-negative bacteria. These proton motive force-dependent transporters generally occur as tripartite efflux complexes that span the cytoplasmic and outer membranes, thus providing a mechanism to ...
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Structure, function and inhibition of RND efflux pumps in Gram-negative bacteria: an update
Current Opinion in Microbiology, 2009Resistance nodulation division efflux systems have a major role in both intrinsic and acquired multi-drug resistance in Gram-negative bacteria. The recent structure of an assembled tripartite system, AcrAB-TolC, revealed that AcrB is docked onto TolC, which remains in an open state once part of the assembled complex and three AcrA molecules complete ...
Jessica M A, Blair, Laura J V, Piddock
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Calcium induces tobramycin resistance in Pseudomonas aeruginosa by regulating RND efflux pumps
Cell Calcium, 2017Pseudomonas aeruginosa is an opportunistic multidrug resistant pathogen causing severe chronic infections. Our previous studies showed that elevated calcium (Ca2+) enhances production of several virulence factors and plant infectivity of the pathogen. Here we show that Ca2+ increases resistance of P.
Sharmily, Khanam +4 more
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