Results 1 to 10 of about 161 (71)

Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats [PDF]

Frontiers in Psychiatry
IntroductionAggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain.
Ilya S. Zhukov, Ilya S. Zhukov, Yazen Alnefeesi, Natalya A. Krotova, Vsevolod V. Nemets, Konstantin A. Demin, Marina N. Karpenko, Evgeny A. Budygin, Evgeny V. Kanov, Evgeny V. Kanov, Allan V. Kalueff, Allan V. Kalueff, Allan V. Kalueff, Allan V. Kalueff, Petr D. Shabanov, Michael Bader, Natalia Alenina, Raul R. Gainetdinov, Raul R. Gainetdinov   +18 more
doaj   +8 more sources

Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397 [PDF]

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor, which signals through elevating intracellular cAMP levels, and expressed in most vertebrates, including rodents and humans.
Stefano Espinoza, Damiana Leo, Damiana Leo, Tatyana D. Sotnikova, Mohammed Shahid, Tiina M. Kääriäinen, Raul R. Gainetdinov, Raul R. Gainetdinov   +7 more
doaj   +10 more sources

Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep [PDF]

Frontiers in Psychiatry
IntroductionThis study aimed to investigate the role of TAAR2-9 in sleep/wake regulation, given TAAR1's known involvement in modulating neurotransmitter release and sleep patterns.MethodsMale TAAR2-9 knockout (KO) and wild-type (WT) mice were compared ...
Sunmee Park, Jasmine Heu, Gavin Scheldrup, Ryan K. Tisdale, Yu Sun, Meghan Haire, Shun-Chieh Ma, Marius C. Hoener, Thomas S. Kilduff   +8 more
doaj   +4 more sources

Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine [PDF]

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (TAAR1) has emerged as a promising target for addiction treatments because it affects dopamine transmission in the mesolimbic pathway.
Ilya Sukhanov, Ilya Sukhanov, Ilya Sukhanov, Mariia Dorofeikova, Antonina Dolgorukova, Artem Dorotenko, Raul R. Gainetdinov, Raul R. Gainetdinov   +7 more
doaj   +3 more sources

TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding [PDF]

Molecular Metabolism
Objective: Metabolic Syndrome, which can be induced or exacerbated by current antipsychotic drugs (APDs), is highly prevalent in schizophrenia patients.
Nina Dedic, Lien Wang, Eva Hajos-Korcsok, Jacob Hecksher-Sørensen, Urmas Roostalu, Steven P. Vickers, Serena Wu, Christoph Anacker, Colleen Synan, Philip G. Jones, Snezana Milanovic, Seth C. Hopkins, Linda J. Bristow, Kenneth S. Koblan   +13 more
doaj   +2 more sources

Trace Amine-Associated Receptor 1 Agonist Modulates Mismatch Negativity-Like Responses in Mice [PDF]

Frontiers in Pharmacology, 2019
The trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor widely expressed in the mammalian brain, particularly in limbic system and monoaminergic areas.
Aleksander A. Aleksandrov, Veronika M. Knyazeva, Anna B. Volnova, Elena S. Dmitrieva, Nadezhda V. Polyakova, Raul R. Gainetdinov   +5 more
doaj   +2 more sources

The versatile binding landscape of the TAAR1 pocket for LSD and other antipsychotic drug molecules

Cell Reports
Summary: Increasing global concerns about psychoactive substance addiction and psychotic disorders highlight the need for comprehensive research into the structure-function relationship governing ligand recognition between these substances and their ...
Kexin Jiang, You Zheng, Liting Zeng, Ling Wang, Fei Li, Jun Pu, Yingli Lu, Suwen Zhao, Fei Xu   +8 more
doaj   +2 more sources

The TAAR1 Agonist PCC0105004 Regulates Amygdala Synaptic Plasticity to Alleviate Anxiety-Like Behaviors in Rats. [PDF]

Pharmacol Res Perspect
ABSTRACT Anxiety disorder is a persistent, widespread, and intractable mood disorder, and the available pharmacotherapies have limited efficacy with significant side effects. Trace amine‐associated receptor 1 (TAAR1) is an emerging drug target for neuropsychiatric disorders.
Zhang Y, Zhang W, Yu L, Shi Y, Xu M, Wang H, Li C, Tian J.   +7 more
europepmc   +2 more sources

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis. [PDF]

Angew Chem Int Ed Engl
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Okunlola GA, Aleku GA.
europepmc   +2 more sources

Selective TAAR1 agonists induce conditioned taste aversion. [PDF]

Psychopharmacology (Berl), 2022
Liu J, Wu R, Johnson B, Zhang Y, Zhu Q, Li JX, Li JX.   +6 more
europepmc   +2 more sources