Results 21 to 30 of about 161 (71)

Therapeutic-like effects of trace amine-associated receptor 1 (TAAR1) activation in models of alcohol abuse

, 2019
Alcohol use disorders (AUD) are one of the most common and devastating forms of drug addiction in Australia. However, current treatments are severely lacking in effective pharmacological options.
James, FLJ (15934265)
core   +1 more source

A partial trace amine-associated receptor 1 agonist exhibits properties consistent with a methamphetamine substitution treatment

, 2016
Recent evidence suggests that the trace amine-associated receptor 1 (TAAR1) plays a pivotal role in the regulation of dopamine (DA) transmission and psychostimulant action.
Hoener, M (15665168), Pei, Y (15665162), Canales, JJ (15665159), Asif-Malik, A (15665165)   +3 more
core  

Keeping up with the therapeutic advances in schizophrenia: A review of novel and emerging pharmacological entities

, 2019
© Cambridge University Press 2019. Schizophrenia remains one of the most severe medical diseases. Current dopamine modulating first-generation and second-generation antipsychotics target mainly positive symptoms, but not/inadequately negative and ...
Von Hardenberg, L., Bödeker, K., Krogmann, A., Correll, C. U., Nöhles, V. B., Peters, L.   +5 more
core   +1 more source

Trace Amine-Associated Receptor 1 agonists reduce alcohol drinking and differentially modulate dopamine release in the nucleus accumbens of alcohol preferring mice

International audienceCurrent treatments for alcohol use disorder have limited efficacy underscoring the need for novel therapeutic targets. Trace amine-associated receptor 1 (TAAR1) is a promising candidate due to its ability to act as a brake on ...
Houdant, Charles, Fouquet, Grégory, Biała, Grażyna, Orzelska-Górka, Jolanta, Lamarche, Mandy, Kruk-Slomka, Marta, Naassila, Mickaël, Jeanblanc, Jérôme, Debuysscher, Véronique   +8 more
core   +1 more source

Selective activation of the trace amine-associated receptor 1 decreases cocaine's reinforcing efficacy and prevents cocaine-induced changes in brain reward thresholds

, 2015
The newly discovered trace amine-associated receptor 1 (TAAR1) has emerged as a promising target for medication development in stimulant addiction due to its ability to regulate dopamine (DA) function and modulate stimulants' effects.
Hoener, MC (15665177), Pei, Y (15665162), Mortas, P (15665174), Canales, JJ (15665159)   +3 more
core  

Neural mechanism of acute stress regulation by trace aminergic signalling in the lateral habenula in male mice. [PDF]

Nat Commun, 2023
Yang SH, Yang E, Lee J, Kim JY, Yoo H, Park HS, Jung JT, Lee D, Chun S, Jo YS, Pyeon GH, Park JY, Lee HW, Kim H.   +13 more
europepmc   +1 more source

Trace amine-associated receptor 1 and drug abuse. [PDF]

Adv Pharmacol, 2022
Wu R, Liu J, Li JX.
europepmc   +1 more source

Potential of Ligands for Trace Amine-Associated Receptor 1 (TAAR1) in the Management of Substance Use Disorders. [PDF]

CNS Drugs, 2021
Wu R, Li JX.
europepmc   +1 more source

Therapeutic Potential of TAAR1 Agonists in Schizophrenia: Evidence from Preclinical Models and Clinical Studies. [PDF]

Int J Mol Sci, 2021
Dedic N, Dworak H, Zeni C, Rutigliano G, Howes OD.   +4 more
europepmc   +1 more source

The Role of Trace Amine-Associated Receptor 1 (TAAR1) in the Pathophysiology and Treatment of Depression. [PDF]

Curr Neuropharmacol
Guan W.
europepmc   +1 more source