Results 11 to 20 of about 161 (71)

Wakefulness Induced by TAAR1 Partial Agonism in Mice Is Mediated Through Dopaminergic Neurotransmission. [PDF]

Int J Mol Sci
Trace amine-associated receptor 1 (TAAR1) is a negative regulator of dopamine (DA) release. The partial TAAR1 agonist RO5263397 promotes wakefulness and suppresses NREM and REM sleep in rodents and non-human primates.
Park S, Heu J, Hoener MC, Kilduff TS.
europepmc   +3 more sources

Methamphetamine-induced impulsivity during chronic methamphetamine treatment in rats: Effects of the TAAR 1 agonist RO5263397. [PDF]

Neuropharmacology, 2018
Xue Z, Siemian JN, Johnson BN, Zhang Y, Li JX.   +4 more
europepmc   +3 more sources

Activation of trace amine-associated receptor 1 attenuates nicotine withdrawal-related effects. [PDF]

Addict Biol, 2022
Nicotine addiction is a leading avoidable brain disorder globally. Although nicotine induces a modest reinforcing effect, which is important for the initial drug use, the transition from nicotine use to nicotine addiction involves the mechanisms ...
Wu R, Liu J, Johnson B, Huang Y, Zhang Y, Li JX, Li JX.   +6 more
europepmc   +2 more sources

Effects of acute and chronic administration of trace amine-associated receptor 1 (TAAR1) ligands on in vivo excitability of central monoamine-secreting neurons in rats. [PDF]

Mol Psychiatry, 2022
Grinchii D, Hoener MC, Khoury T, Dekhtiarenko R, Nejati Bervanlou R, Jezova D, Dremencov E.   +6 more
europepmc   +2 more sources

The selective TAAR1 partial agonist RO5263397 promoted novelty recognition memory in mice. [PDF]

Psychopharmacology (Berl), 2021
Wu R, Liu J, Seaman R, Johnson B, Zhang Y, Li JX, Li JX.   +6 more
europepmc   +2 more sources

Effects of the Trace Amine-Associated Receptor 1 Agonist RO5263397 on Abuse-Related Effects of Cocaine in Rats

Neuropsychopharmacology, 2014
Yanyan Qiu, Jun-Xu Li, Yanan Zhang, David A Thorn, Chad M Galuska, David M Dietz, Li Jing, Amy M Gancarz-Kausch   +7 more
core   +2 more sources

Activation of trace amine-associated receptor 1 selectively attenuates the reinforcing effects of morphine. [PDF]

Br J Pharmacol, 2021
Liu J, Seaman R, Johnson B, Wu R, Vu J, Tian J, Zhang Y, Li JX.   +7 more
europepmc   +2 more sources

Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats

Behavioural Pharmacology, 2017
Jun-Xu Li, Yanan Zhang, Justin N. Siemian   +2 more
core   +2 more sources

A partial trace amine-associated receptor 1 agonist exhibits properties consistent with a methamphetamine substitution treatment:TAAR1 and methamphetamine [PDF]

, 2017
Recent evidence suggests that the trace amine-associated receptor 1 (TAAR1) plays a pivotal role in the regulation of dopamine (DA) transmission and psychostimulant action.
Asif-Malik, Aman; id_orcid, Hoener, Marius, Pei, Yue, Canales, Juan J.   +3 more
core   +1 more source

Discovery and Characterization of 2‑Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists

, 2016
2-Aminooxazolines were discovered as a novel structural class of TAAR1 ligands. Starting from a known adrenergic compound 1, structural modifications were made to obtain highly potent and selective TAAR1 ligands such as 12 (RO5166017), 18 (RO5256390), 36
Dietrich Türck (1398787), Marius C. Hoener (166578), Philipp Schmid (1398796), Robert Unger (1398805), Roger D. Norcross (1398814), Susanne Mohr (1387113), Guillaume Décoret (1398808), Roman Hutter (1398793), Axel Pähler (1398817), Annick Goergler (1398811), Katrin Groebke Zbinden (1398799), Angélica Beurier (1398802), Guido Galley (1398790)   +12 more
core   +1 more source