TAAR1-mediated pathways regulating nigrostriatal function and the discovery and pharmacological characterization of a novel TAAR1 agonist, Selutaront [PDF]
Frontiers in PharmacologyIntroductionSchizophrenia is a severe neurodevelopmental disorder with limited treatment options. Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target, yet its downstream signaling mechanisms and the development of ...
Jianzhao Zhang +8 more
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New Insights into Complex PTSD Treatment: Focus on TAAR1 Agonists [PDF]
BiomedicinesBackground/Objectives: The therapeutic potential of selective trace amine-associated receptor 1 (TAAR1) agonists has been established in multiple animal models of depression and anxiety.
David-Mandl V. Tseilikman +12 more
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The TAAR1 antagonist EPPTB ameliorates colitis via serotonin inhibition [PDF]
Biochemistry and Biophysics ReportsInflammatory bowel disease (IBD) is characterized by gut dysbiosis and impaired microbial metabolite signaling. Emerging evidence suggests that gut microbial metabolites, such as trace amines (tryptamine, phenethylamine, and tyramine), function as ...
Leyi Luo +7 more
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TAAR1 deficiency impairs mitochondrial dynamics and synaptic integrity in the medial prefrontal cortex and associated cognition in mice [PDF]
Translational PsychiatryAccumulating evidence suggests that the trace amine-associated receptor 1 (TAAR1) in the medial prefrontal cortex (mPFC) is involved in modulating some areas of behavior related to psychiatric disorders and neurochemical transmission, but the molecular ...
Xian-Qiang Zhang +7 more
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Discovery of a Novel Chemo-Type for TAAR1 Agonism via Molecular Modeling
MoleculesThe search for novel effective TAAR1 ligands continues to draw great attention due to the wide range of pharmacological applications related to TAAR1 targeting. Herein, molecular docking studies of known TAAR1 ligands, characterized by an oxazoline core,
Elena Cichero +2 more
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Structure-based identification of bioactive compounds as trace amine-associated receptor 1 agonists for the therapeutic management of major depressive disorder. [PDF]
PLoS ONEThe global burden of major depressive disorder (MDD) drives ongoing efforts to develop safer and more targeted treatment strategies. Modern advances have identified trace amine-associated receptor 1 (TAAR1) as a promising non-monoaminergic target with ...
Abdelbaset Mohamed Elasbali +5 more
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Trace amine-associated receptors as potential targets for the treatment of anxiety and depression [PDF]
Frontiers in PharmacologyIn the metabolic pathways associated with major biogenic amines, such as dopamine, noradrenaline, and serotonin, there exists a group of compounds known as trace amines.
Zelong Li +5 more
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Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice
Brain Sciences, 2022 It is known that the trace amine-associated receptor 1 (TAAR1) receptor is involved in limbic brain functions by regulating dopamine transmission and putative reward circuitry.
Ilya S. Zhukov +7 more
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Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors
Frontiers in Psychiatry, 2021 Sensitivity to rewarding and reinforcing drug effects has a critical role in initial use, but the role of initial aversive drug effects has received less attention.
Tamara J. Phillips +8 more
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Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells
Cells, 2021 Trace amine-associated receptor 1 (rodent Taar1/human TAAR1) is a G protein-coupled receptor that is mainly recognized for its functions in neuromodulation.
Maria Qatato +8 more
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