Results 1 to 10 of about 37,032,341 (244)

Unlocking the Therapeutic Potential of Ulotaront as a Trace Amine-Associated Receptor 1 Agonist for Neuropsychiatric Disorders [PDF]

Biomedicines, 2023
All antipsychotics currently used in clinic block D2 dopamine receptors. Trace amine-associated receptor 1 is emerging as a new therapeutic target for schizophrenia and several other neuropsychiatric disorders.
Savelii R. Kuvarzin, Ilya Sukhanov, Kirill Onokhin, Konstantin Zakharov, Raul R. Gainetdinov   +4 more
doaj   +5 more sources

Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward [PDF]

Frontiers in Pharmacology, 2018
Eating disorders and some forms of obesity are characterized by addictive-like, compulsive eating behavior which contains numerous similarities with compulsive drug use.
Catherine F. Moore, Catherine F. Moore, Valentina Sabino, Pietro Cottone   +3 more
doaj   +6 more sources

Molecular basis of human trace amine-associated receptor 1 activation [PDF]

Nature Communications, 2023
The human trace amine-associated receptor 1 (hTAAR1, hTA1) is a key regulator of monoaminergic neurotransmission and the actions of psychostimulants. Despite preclinical research demonstrating its tractability as a drug target, its molecular mechanisms ...
Gregory Zilberg, Alexandra K. Parpounas, Audrey L. Warren, Shifan Yang, Daniel Wacker   +4 more
doaj   +5 more sources

Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells [PDF]

Cells, 2021
Trace amine-associated receptor 1 (rodent Taar1/human TAAR1) is a G protein-coupled receptor that is mainly recognized for its functions in neuromodulation.
Maria Qatato, Vaishnavi Venugopalan, Alaa Al-Hashimi, Maren Rehders, Aaron D. Valentine, Zeynep Hein, Uillred Dallto, Sebastian Springer, Klaudia Brix   +8 more
doaj   +4 more sources

Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders [PDF]

Frontiers in Pharmacology, 2019
Background: The G protein–coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1) is expressed across brain areas involved in emotions, reward and cognition, and modulates monoaminergic and glutamatergic neurotransmissions.
Grazia Rutigliano, Grazia Rutigliano, Julia Bräunig, Claudia Del Grande, Vittoria Carnicelli, Isabella Masci, Sergio Merlino, Gunnar Kleinau, Luca Tessieri, Simone Pardossi, Sarah Paisdzior, Liliana Dell’Osso, Heike Biebermann, Riccardo Zucchi   +13 more
doaj   +6 more sources

Trace amine-associated receptor 1 regulation of Kv1.4 channels in trigeminal ganglion neurons contributes to nociceptive behaviors [PDF]

The Journal of Headache and Pain, 2023
Background Trace amines, such as tyramine, are endogenous amino acid metabolites that have been hypothesized to promote headache. However, the underlying cellular and molecular mechanisms remain unknown.
Yuan Zhang, Hua Wang, Yufang Sun, Zitong Huang, Yu Tao, Yiru Wang, Xinghong Jiang, Jin Tao   +7 more
doaj   +2 more sources

Protein Metabolism Changes and Alterations in Behavior of Trace Amine-Associated Receptor 1 Knockout Mice Fed a High-Fructose Diet [PDF]

Neurology International, 2023
Trace amines and their receptors are a family of G protein-coupled receptors widely distributed in the central nervous system and periphery. The trace amine-associated receptor 1 (TAAR1) plays a significant role as a therapeutic target for schizophrenia,
Sergey A. Apryatin, Ilya S. Zhukov, Ekaterina A. Zolotoverkhaya, Saveliy R. Kuvarzin, Temirkan A. Khunagov, Sanelya V. Ushmugina, Victor M. Klimenko   +6 more
doaj   +2 more sources

Unlocking the secrets of trace amine-associated receptor 1 agonists: new horizon in neuropsychiatric treatment [PDF]

Frontiers in Psychiatry
For over seven decades, dopamine receptor 2 (D2 receptor) antagonists remained the mainstay treatment for neuropsychiatric disorders. Although it is effective for treating hyperdopaminergic symptoms, it is often ineffective for treating negative and ...
Britto Shajan, Tarun Bastiampillai, Tarun Bastiampillai, Shane D. Hellyer, Pramod C. Nair, Pramod C. Nair, Pramod C. Nair, Pramod C. Nair   +7 more
doaj   +2 more sources

Discovery of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 2-(5-(4′-Chloro-[1,1′-biphenyl]-4-yl)-4H-1,2,4-triazol-3-yl)ethan-1-amine (LK00764) for the Treatment of Psychotic Disorders [PDF]

Biomolecules, 2022
A focused in-house library of about 1000 compounds comprising various heterocyclic motifs in combination with structural fragments similar to β-phenylethylamine or tyramine was screened for the agonistic activity towards trace amine-associated receptor 1
Mikhail Krasavin, Alexey Lukin, Ilya Sukhanov, Andrey S. Gerasimov, Savelii Kuvarzin, Evgeniya V. Efimova, Mariia Dorofeikova, Anna Nichugovskaya, Andrey Matveev, Kirill Onokhin, Konstantin Zakharov, Maxim Gureev, Raul R. Gainetdinov   +12 more
doaj   +2 more sources

Structure-based identification of bioactive compounds as trace amine-associated receptor 1 agonists for the therapeutic management of major depressive disorder. [PDF]

PLoS ONE
The global burden of major depressive disorder (MDD) drives ongoing efforts to develop safer and more targeted treatment strategies. Modern advances have identified trace amine-associated receptor 1 (TAAR1) as a promising non-monoaminergic target with ...
Abdelbaset Mohamed Elasbali, Ahmed S Ali, Mohd Adnan, Taj Mohammad, Anas Shamsi, Md Imtaiyaz Hassan   +5 more
doaj   +3 more sources