Results 1 to 10 of about 1,066 (152)

Trace Amine Associated Receptor 1 (TAAR1) Modulation of Food Reward [PDF]

Frontiers in Pharmacology, 2018
Eating disorders and some forms of obesity are characterized by addictive-like, compulsive eating behavior which contains numerous similarities with compulsive drug use.
Catherine F. Moore, Catherine F. Moore, Valentina Sabino, Pietro Cottone   +3 more
doaj   +5 more sources

Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397 [PDF]

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor, which signals through elevating intracellular cAMP levels, and expressed in most vertebrates, including rodents and humans.
Stefano Espinoza, Damiana Leo, Damiana Leo, Tatyana D. Sotnikova, Mohammed Shahid, Tiina M. Kääriäinen, Raul R. Gainetdinov, Raul R. Gainetdinov   +7 more
doaj   +9 more sources

Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer. [PDF]

Int J Mol Sci, 2021
Trace amine-associated receptor 1 (TAAR1) is a Gαs- protein coupled receptor that plays an important role in the regulation of the immune system and neurotransmission in the CNS. In ovarian cancer cell lines, stimulation of TAAR1 via 3-iodothyronamine (T1AM) reduces cell viability and induces cell death and DNA damage. Aim of this study was to evaluate
Vogelsang TLR, Vattai A, Schmoeckel E, Kaltofen T, Chelariu-Raicu A, Zheng M, Mahner S, Mayr D, Jeschke U, Trillsch F.   +9 more
europepmc   +6 more sources

Discovery of Trace Amine-Associated Receptor 1 (TAAR1) Agonist 2-(5-(4′-Chloro-[1,1′-biphenyl]-4-yl)-4H-1,2,4-triazol-3-yl)ethan-1-amine (LK00764) for the Treatment of Psychotic Disorders [PDF]

Biomolecules, 2022
A focused in-house library of about 1000 compounds comprising various heterocyclic motifs in combination with structural fragments similar to β-phenylethylamine or tyramine was screened for the agonistic activity towards trace amine-associated receptor 1
Mikhail Krasavin, Alexey Lukin, Ilya Sukhanov, Andrey S. Gerasimov, Savelii Kuvarzin, Evgeniya V. Efimova, Mariia Dorofeikova, Anna Nichugovskaya, Andrey Matveev, Kirill Onokhin, Konstantin Zakharov, Maxim Gureev, Raul R. Gainetdinov   +12 more
doaj   +2 more sources

Trace amine-associated receptor 1 (TAAR1) agonism for psychosis: a living systematic review and meta-analysis of human and non-human data [version 1; peer review: 2 approved] [PDF]

Wellcome Open Research
Background Trace amine-associated receptor 1 (TAAR1) agonism shows promise for treating psychosis, prompting us to synthesise data from human and non-human studies.
Fiona J. Ramage, Spyridon Siafis, Edoardo G. Ostinelli, Virginia Chiocchia, Claire Stansfield, Simonne Wright, Ioannis Mantas, Damian Omari Juma, Grazia Rutigliano, Oliver D. Howes, Francesca Tinsdeall, Lea Milligan, Claire Friedrich, Julian H. Elliott, Carmen Moreno, Ava Homiar, James Thomas, Emily S. Sena, Malcolm R. Macleod, Charlotte Austin, Nobuyuki Nomura, Jaycee Kennett, Soraya Seedat, Luke J. Vano, Andrea Cipriani, Olena Maksym, Jennifer Potts, David Gilbert, Thomy Tonia, Robert A. McCutcheon, Matthias Egger, Stefan Leucht, Toshi A. Furukawa, Hossein Dehdarirad, Janna Hastings, Susan Michie, Georgia Salanti, Olufisayo Elugbadebo, Ouma Simple   +38 more
doaj   +2 more sources

TAAR1-mediated pathways regulating nigrostriatal function and the discovery and pharmacological characterization of a novel TAAR1 agonist, Selutaront [PDF]

Frontiers in Pharmacology
IntroductionSchizophrenia is a severe neurodevelopmental disorder with limited treatment options. Trace amine-associated receptor 1 (TAAR1) has emerged as a promising therapeutic target, yet its downstream signaling mechanisms and the development of ...
Jianzhao Zhang, Xuan Deng, Jiawei Lv, Jing Lu, Lin Wang, Wenyan Wang, Hui Lei, Yunjie Wang, Jingwei Tian   +8 more
doaj   +2 more sources

New Insights into Complex PTSD Treatment: Focus on TAAR1 Agonists [PDF]

Biomedicines
Background/Objectives: The therapeutic potential of selective trace amine-associated receptor 1 (TAAR1) agonists has been established in multiple animal models of depression and anxiety.
David-Mandl V. Tseilikman, Vadim E. Tseilikman, Vladislav A. Shatilov, Daria A. Obukhova, Ilya S. Zhukov, Ivan V. Yatsyk, Victoria A. Maistrenko, Vladimir A. Shipelin, Nikita V. Trusov, Marina N. Karpenko, Olga B. Tseilikman, Raul R. Gainetdinov, Jurica Novak   +12 more
doaj   +2 more sources

Structure-based identification of bioactive compounds as trace amine-associated receptor 1 agonists for the therapeutic management of major depressive disorder. [PDF]

PLoS ONE
The global burden of major depressive disorder (MDD) drives ongoing efforts to develop safer and more targeted treatment strategies. Modern advances have identified trace amine-associated receptor 1 (TAAR1) as a promising non-monoaminergic target with ...
Abdelbaset Mohamed Elasbali, Ahmed S Ali, Mohd Adnan, Taj Mohammad, Anas Shamsi, Md Imtaiyaz Hassan   +5 more
doaj   +2 more sources

TAAR1 deficiency impairs mitochondrial dynamics and synaptic integrity in the medial prefrontal cortex and associated cognition in mice [PDF]

Translational Psychiatry
Accumulating evidence suggests that the trace amine-associated receptor 1 (TAAR1) in the medial prefrontal cortex (mPFC) is involved in modulating some areas of behavior related to psychiatric disorders and neurochemical transmission, but the molecular ...
Xian-Qiang Zhang, Jing Xiong, De-Nong Liu, Chen-Chen Zhang, Yanan Zhang, Ji-Tao Li, Tian-Mei Si, Yun-Ai Su   +7 more
doaj   +2 more sources

Enhanced Aggression, Reduced Self-Grooming Behavior and Altered 5-HT Regulation in the Frontal Cortex in Mice Lacking Trace Amine-Associated Receptor 1 (TAAR1). [PDF]

Int J Mol Sci, 2022
Zhukov IS, Karpova IV, Krotova NA, Tissen IY, Demin KA, Shabanov PD, Budygin EA, Kalueff AV, Gainetdinov RR.   +8 more
europepmc   +2 more sources