Results 21 to 30 of about 1,066 (152)

Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets

Biomolecules, 2023
Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are ...
Anastasia N. Vaganova, Taisiia S. Shemyakova, Karina V. Lenskaia, Roman N. Rodionov, Charlotte Steenblock, Raul R. Gainetdinov   +5 more
doaj   +1 more source

Evaluation of Approach to a Conspecific and Blood Biochemical Parameters in TAAR1 Knockout Mice

Brain Sciences, 2022
It is known that the trace amine-associated receptor 1 (TAAR1) receptor is involved in limbic brain functions by regulating dopamine transmission and putative reward circuitry.
Ilya S. Zhukov, Maria A. Ptukha, Ekaterina A. Zolotoverkhaja, Ekaterina L. Sinitca, Ilya Y. Tissen, Inessa V. Karpova, Anna B. Volnova, Raul R. Gainetdinov   +7 more
doaj   +1 more source

Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites. [PDF]

Bioorg Med Chem Lett, 2008
Amiodarone (Cordarone, Wyeth-Ayerst Pharmaceuticals) is a clinically available drug used to treat a wide variety of cardiac arrhythmias. We report here the synthesis and characterization of a panel of potential amiodarone metabolites that have significant structural similarity to thyroid hormone and its metabolites the iodothyronamines.
Snead AN, Miyakawa M, Tan ES, Scanlan TS.   +3 more
europepmc   +4 more sources

Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs

BMC Evolutionary Biology, 2010
Background The trace amine associated receptor family is a diverse array of GPCRs that arose before the first vertebrates walked on land. Trace amine associated receptor 1 (TAAR1) is a wide spectrum aminergic receptor that acts as a modulator in brain ...
Westmoreland Susan V, Xie Zhihua, Vallender Eric J, Miller Gregory M   +3 more
doaj   +1 more source

The dopamine metabolite 3-methoxytyramine is a neuromodulator. [PDF]

PLoS ONE, 2010
Dopamine (3-hydroxytyramine) is a well-known catecholamine neurotransmitter involved in multiple physiological functions including movement control. Here we report that the major extracellular metabolite of dopamine, 3-methoxytyramine (3-MT), can induce ...
Tatyana D Sotnikova, Jean-Martin Beaulieu, Stefano Espinoza, Bernard Masri, Xiaodong Zhang, Ali Salahpour, Larry S Barak, Marc G Caron, Raul R Gainetdinov   +8 more
doaj   +1 more source

Minimal Age-Related Alterations in Behavioral and Hematological Parameters in Trace Amine-Associated Receptor 1 (TAAR1) Knockout Mice. [PDF]

Cell Mol Neurobiol, 2020
Since the discovery in 2001, the G protein-coupled trace amine-associated receptor 1 (TAAR1) has become an important focus of research targeted on evaluation of its role in the central nervous system (CNS). Meanwhile, impact of TAAR1 in the peripheral organs is less investigated.
Zhukov IS, Kubarskaya LG, Tissen IY, Kozlova AA, Dagayev SG, Kashuro VA, Vlasova OL, Sinitca EL, Karpova IV, Gainetdinov RR.   +9 more
europepmc   +3 more sources

Regulation by Trace Amine-Associated Receptor 1 (TAAR1) of Dopaminergic-GABAergic Interaction in the Striatum: Effects of the Enhancer Drug (-)BPAP. [PDF]

Neurochem Res
Abstract Although it is well documented that the striatal GABAergic projection neurons receive excitatory and inhibitory dopaminergic innervation via D1 and D2 receptors, the trace amine-associated receptor 1 (TAAR1)-mediated regulation of this neural connection is much less studied.
Harsing LG, Szénási G, Fehér B, Miklya I.   +3 more
europepmc   +3 more sources

Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

eLife, 2019
We identified a locus on mouse chromosome 10 that accounts for 60% of the genetic variance in methamphetamine intake in mice selectively bred for high versus low methamphetamine consumption. We nominated the trace amine-associated receptor 1 gene, Taar1,
Alexandra M Stafford, Cheryl Reed, Harue Baba, Nicole AR Walter, John RK Mootz, Robert W Williams, Kim A Neve, Lev M Fedorov, Aaron J Janowsky, Tamara J Phillips   +9 more
doaj   +1 more source

Protein Metabolism Changes and Alterations in Behavior of Trace Amine-Associated Receptor 1 Knockout Mice Fed a High-Fructose Diet

Neurology International, 2023
Trace amines and their receptors are a family of G protein-coupled receptors widely distributed in the central nervous system and periphery. The trace amine-associated receptor 1 (TAAR1) plays a significant role as a therapeutic target for schizophrenia,
Sergey A. Apryatin, Ilya S. Zhukov, Ekaterina A. Zolotoverkhaya, Saveliy R. Kuvarzin, Temirkan A. Khunagov, Sanelya V. Ushmugina, Victor M. Klimenko   +6 more
doaj   +1 more source

TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg

Frontiers in Pharmacology, 2018
Trace-amine associated receptor 1 (TAAR1) is the best-characterized member of the family of TAARs. TAAR1 is broadly expressed in the brain, especially within the monoaminergic systems.
Jian-Feng Liu, Jian-Feng Liu, Jun-Xu Li
doaj   +1 more source