Results 31 to 40 of about 1,066 (152)

Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells

Cells, 2021
Trace amine-associated receptor 1 (rodent Taar1/human TAAR1) is a G protein-coupled receptor that is mainly recognized for its functions in neuromodulation.
Maria Qatato, Vaishnavi Venugopalan, Alaa Al-Hashimi, Maren Rehders, Aaron D. Valentine, Zeynep Hein, Uillred Dallto, Sebastian Springer, Klaudia Brix   +8 more
doaj   +1 more source

Trace amine‐associated receptor 1 (TAAR1) modulates dopaminergic activity

The FASEB Journal, 2008
The recent identification of the trace amine associated receptor 1 (TAAR1) provides an opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor‐mediated effects. In order to separate both effects on a physiological level, a Taar1 ‐deficient mouse line ...
Marius Christian Hoener, Lothar Lindemann, Claas Aiko Meyer, Karine Jeanneau, Amyaouch Bradaia, Laurence Ozmen, Bernhard Bettler, Joseph G Wettstein, Edilio Borroni, Jean‐Luc Moreau   +9 more
openaire   +1 more source

Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry and Clinical Implications

Frontiers in Neuroscience, 2016
Biogenic amines are a collection of endogenous molecules that play pivotal roles as neurotransmitters and hormones. In addition to the classical biogenic amines resulting from decarboxylation of aromatic acids, including dopamine (DA), norepinephrine ...
Yue ePei, Aman eAsif-Malik, Juan J Canales   +2 more
doaj   +1 more source

Non-Functional Trace Amine-Associated Receptor 1 Variants in Patients With Mental Disorders

Frontiers in Pharmacology, 2019
Background: The G protein–coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR1) is expressed across brain areas involved in emotions, reward and cognition, and modulates monoaminergic and glutamatergic neurotransmissions.
Grazia Rutigliano, Grazia Rutigliano, Julia Bräunig, Claudia Del Grande, Vittoria Carnicelli, Isabella Masci, Sergio Merlino, Gunnar Kleinau, Luca Tessieri, Simone Pardossi, Sarah Paisdzior, Liliana Dell’Osso, Heike Biebermann, Riccardo Zucchi   +13 more
doaj   +1 more source

Confirmation of a Causal Taar1 Allelic Variant in Addiction-Relevant Methamphetamine Behaviors

Frontiers in Psychiatry, 2021
Sensitivity to rewarding and reinforcing drug effects has a critical role in initial use, but the role of initial aversive drug effects has received less attention.
Tamara J. Phillips, Tamara J. Phillips, Tyler Roy, Sara J. Aldrich, Harue Baba, Jason Erk, John R. K. Mootz, Cheryl Reed, Elissa J. Chesler   +8 more
doaj   +1 more source

Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers

European Neuropsychopharmacology, 2015
Trace amine-associated receptor 1 (TAAR1) activation by selective endogenous agonists modulates dopaminergic neurotransmission. This results in antipsychotic-like behavior in vivo which might be initiated by an interaction of TAAR1 and dopamine D2L receptor (D2R).
Harmeier, A., Obermueller, S., Meyer, C. A., Revel, F. G., Buchy, D., Chaboz, S., Dernick, G., Wettstein, J. G., Iglesias, A., Rolink, A., Bettler, B., Hoener, M. C.   +11 more
openaire   +5 more sources

Novel 1-Amidino-4-Phenylpiperazines as Potent Agonists at Human TAAR1 Receptor: Rational Design, Synthesis, Biological Evaluation and Molecular Docking Studies

Pharmaceuticals, 2020
Targeting trace amine-associated receptor 1 (TAAR1) receptor continues to offer an intriguing opportunity to develop innovative therapies in different pharmacological settings.
Valeria Francesconi, Elena Cichero, Evgeny V. Kanov, Erik Laurini, Sabrina Pricl, Raul R. Gainetdinov, Michele Tonelli   +6 more
doaj   +1 more source

Biological evaluation and in silico studies of novel compounds as potent TAAR1 agonists that could be used in schizophrenia treatment

Frontiers in Pharmacology, 2023
Introduction: Schizophrenia is a serious mental illness that requires effective treatment with minimal adverse effects. As preclinical and clinical research progresses, trace amine-associated receptor 1 (TAAR1) is becoming a potential new target for the ...
Yunjie Wang, Zhaofeng Liu, Jing Lu, Wenyan Wang, Lin Wang, Yifei Yang, Hongbo Wang, Liang Ye, Jianzhao Zhang, Jingwei Tian   +9 more
doaj   +1 more source

Methamphetamine induces trace amine-associated receptor 1 (TAAR1) expression in human T lymphocytes: role in immunomodulation. [PDF]

J Leukoc Biol, 2016
Abstract The novel transmembrane G protein-coupled receptor, trace amine-associated receptor 1 (TAAR1), represents a potential, direct target for drugs of abuse and monoaminergic compounds, including amphetamines. For the first time, our studies have illustrated that there is an induction of TAAR1 mRNA expression in resting T lymphocytes
Sriram U, Cenna JM, Haldar B, Fernandes NC, Razmpour R, Fan S, Ramirez SH, Potula R.   +7 more
europepmc   +3 more sources

Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine

Frontiers in Pharmacology, 2018
Trace amine-associated receptor 1 (TAAR1) has emerged as a promising target for addiction treatments because it affects dopamine transmission in the mesolimbic pathway.
Ilya Sukhanov, Ilya Sukhanov, Ilya Sukhanov, Mariia Dorofeikova, Antonina Dolgorukova, Artem Dorotenko, Raul R. Gainetdinov, Raul R. Gainetdinov   +7 more
doaj   +1 more source