Results 11 to 20 of about 1,066 (152)

Role of Glial Trace Amine Associated Receptor 1 (TAAR1) and Microbiota in Schizophrenia. [PDF]

Neurochem Res
Trace amine-associated receptors (TAARs) are a class of G protein-coupled receptors that respond to metabolic derivatives of the amino acids such as phenylalanine, tyrosine, and tryptophan. Trace amines derive their name from the fact that their concentration in the periphery as well as in the central nervous system (CNS) is in trace amounts compared ...
Tsytsarev V, Vaganova AN, Volnova A, Fesenko Z, Getachew B, Gainetdinov RR, Tizabi Y.   +6 more
europepmc   +4 more sources

Avenues for the development of therapeutics that target trace amine associated receptor 1 (TAAR1). [PDF]

J Med Chem, 2012
Miller GM.
europepmc   +5 more sources

Increased trace amine-associated receptor 1 (TAAR1) expression is associated with a positive survival rate in patients with breast cancer. [PDF]

J Cancer Res Clin Oncol, 2017
A correlation between breast cancer and thyroid disorders has been described in previous studies. Degraded thyroid hormones are referred to as trace amines. These endogenous amines have the ability to bind to the G-protein-coupled receptor TAAR1 (trace amine-associated receptor) and thereby activate it.
Vattai A, Akyol E, Kuhn C, Hofmann S, Heidegger H, von Koch F, Hermelink K, Wuerstlein R, Harbeck N, Mayr D, Spitzweg C, Toth B, Mahner S, Jeschke U, Ditsch N.   +14 more
europepmc   +5 more sources

Potential of Ligands for Trace Amine-Associated Receptor 1 (TAAR1) in the Management of Substance Use Disorders. [PDF]

CNS Drugs, 2021
Trace amines, including β-phenylethylamine (β-PEA), p-tyramine (TYR), tryptamine (TRP), and p-octopamine (OCT), represent a group of amines expressed at low levels in the mammalian brain. Given the close structural similarities to traditional monoamines, links between trace amines and the monoaminergic system have long been suspected.
Wu R, Li JX.
europepmc   +4 more sources

Trace Amine-Associated Receptor 1 (TAAR1): Molecular and Clinical Insights for the Treatment of Schizophrenia and Related Comorbidities. [PDF]

ACS Pharmacol Transl Sci, 2022
Schizophrenia is a complex and severe mental illness. Current treatments for schizophrenia typically modulate dopaminergic neurotransmission by D2-receptor blockade. While reducing positive symptoms of schizophrenia, current antipsychotic drugs have little clinical effect on negative symptoms and cognitive impairments.
Nair PC, Chalker JM, McKinnon RA, Langmead CJ, Gregory KJ, Bastiampillai T.   +5 more
europepmc   +4 more sources

Actions of Trace Amines in the Brain-Gut-Microbiome Axis via Trace Amine-Associated Receptor-1 (TAAR1). [PDF]

Cell Mol Neurobiol, 2020
Trace amines and their primary receptor, Trace Amine-Associated Receptor-1 (TAAR1) are widely studied for their involvement in the pathogenesis of neuropsychiatric disorders despite being found in the gastrointestinal tract at physiological levels. With the emergence of the "brain-gut-microbiome axis," we take the opportunity to review what is known ...
Bugda Gwilt K, González DP, Olliffe N, Oller H, Hoffing R, Puzan M, El Aidy S, Miller GM.   +7 more
europepmc   +5 more sources

The TAAR1 Agonist PCC0105004 Regulates Amygdala Synaptic Plasticity to Alleviate Anxiety‐Like Behaviors in Rats

Pharmacology Research & Perspectives
Anxiety disorder is a persistent, widespread, and intractable mood disorder, and the available pharmacotherapies have limited efficacy with significant side effects.
Yingtian Zhang, Wei Zhang, Linyao Yu, Yaoqin Shi, Min Xu, Hui Wang, Chunmei Li, Jingwei Tian   +7 more
doaj   +2 more sources

The Role of Trace Amine-Associated Receptor 1 (TAAR1) in the Pathophysiology and Treatment of Depression. [PDF]

Curr Neuropharmacol
Depression is a chronic and recurrent psychiatric condition believed to result from an interaction between genetic susceptibility and environmental stimuli. Although current therapies prescribed for depression can be effective, it will take several weeks to demonstrate their full effectiveness and is often ...
Guan W.
europepmc   +3 more sources

Trace amine-associated receptor 1 (TAAR1) promotes anti-diabetic signaling in insulin-secreting cells. [PDF]

J Biol Chem, 2019
Pancreatic β-cell failure in type 2 diabetes mellitus is a serious challenge that results in an inability of the pancreas to produce sufficient insulin to properly regulate blood glucose levels. Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor expressed by β-cells that has recently been proposed as a potential target for ...
Michael ES, Covic L, Kuliopulos A.
europepmc   +4 more sources

Trace amine-associated receptor 1 (TAAR1) agonists

Archives of Psychiatry Research, 2022
Overview of current developments about trace amine- associated receptor 1 (TAAR1 ...
Peitl, Vjekoslav, Vlahović, Darko
openaire   +3 more sources