Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine [PDF]
Frontiers in Pharmacology, 2018 Trace amines (TAs), endogenous amino acid metabolites that are structurally similar to the biogenic amines, are endogenous ligands for trace amine-associated receptor 1 (TAAR1), a GPCR that modulates dopaminergic, serotonergic, and glutamatergic activity.
Michael D. Schwartz +4 more
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Frontiers in Pharmacology, 2018 Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor, which signals through elevating intracellular cAMP levels, and expressed in most vertebrates, including rodents and humans.
Stefano Espinoza +7 more
doaj +3 more sources
Trace Amine-Associated Receptor 1 Agonist Modulates Mismatch Negativity-Like Responses in Mice [PDF]
Frontiers in Pharmacology, 2019 The trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor widely expressed in the mammalian brain, particularly in limbic system and monoaminergic areas.
Aleksander A. Aleksandrov +5 more
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Biomolecules, 2023 Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are ...
Anastasia N. Vaganova +5 more
doaj +3 more sources
Trace Amine-Associated Receptor 1 Modulates the Locomotor and Sensitization Effects of Nicotine [PDF]
Frontiers in Pharmacology, 2018 Trace amine-associated receptor 1 (TAAR1) has emerged as a promising target for addiction treatments because it affects dopamine transmission in the mesolimbic pathway.
Ilya Sukhanov +7 more
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Imaging the trace amine-associated receptor 1 by positron emission tomography
Tetrahedron Letters, 2021 Abstract Trace amine-associated receptor 1 (TAAR1) has been implicated in drug addiction, schizophrenia, depression and Parkinson’s disease (PD). To date, there are no reports on TAAR1-targeted probes for non-invasive quantification of receptor density in vivo.
Jiyun Sun +10 more
openaire +2 more sources
Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs [PDF]
BMC Evolutionary Biology, 2010 Background The trace amine associated receptor family is a diverse array of GPCRs that arose before the first vertebrates walked on land. Trace amine associated receptor 1 (TAAR1) is a wide spectrum aminergic receptor that acts as a modulator in brain ...
Westmoreland Susan V +3 more
doaj +2 more sources
Collective and Coordinated Conformational Changes Determine Agonism or Antagonism at the Human Trace Amine-Associated Receptor 1 [PDF]
ACS Omega, 2023 Agustín I. Robles +3 more
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Trace amine-associated receptor 1 and drug abuse. [PDF]
Adv Pharmacol, 2022 Trace amine-associated receptor 1 (TAAR1) is the best characterized receptor selectively activated by trace amines. It is broadly expressed in the monoaminergic system in the brain including ventral tegmental area (VTA), nucleus accumbens (NAc), dorsal raphe (DR) and substantial nigra (SN). Extensive studies have suggested that TAAR1 plays an important
Wu R, Liu J, Li JX.
europepmc +3 more sources
Elucidating the molecular pharmacology of trace amine‐associated receptor 1 to advance antipsychotic drug discovery [PDF]
Clinical and Translational MedicineJingjing Yu +3 more
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