Results 11 to 20 of about 37,032,341 (244)

Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry and Clinical Implications [PDF]

Frontiers in Neuroscience, 2016
Biogenic amines are a collection of endogenous molecules that play pivotal roles as neurotransmitters and hormones. In addition to the classical biogenic amines resulting from decarboxylation of aromatic acids, including dopamine (DA), norepinephrine ...
Yue ePei, Aman eAsif-Malik, Juan J Canales   +2 more
doaj   +14 more sources

Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol [PDF]

Substance Abuse: Research and Treatment, 2013
Background Few treatment options for alcohol use disorders (AUDs) exist and more are critically needed. Here, we assessed whether trace amine associated receptor 1 (TAAR1), a modulator of brain monoamine systems, is involved in the behavioral and ...
Laurie J. Lynch, Katherine A. Sullivan, Eric J. Vallender, James K. Rowlett, Donna M. Platt, Gregory M. Miller   +5 more
doaj   +8 more sources

Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists.

PLoS ONE, 2011
Trace amine-associated receptors (TAAR) are rhodopsin-like G-protein-coupled receptors (GPCR). TAAR are involved in modulation of neuronal, cardiac and vascular functions and they are potentially linked with neurological disorders like schizophrenia and ...
Gunnar Kleinau, Juliane Pratzka, Daniela Nürnberg, Annette Grüters, Dagmar Führer-Sakel, Heiko Krude, Josef Köhrle, Torsten Schöneberg, Heike Biebermann   +8 more
doaj   +6 more sources

Trace amine-associated receptor 1 (TAAR1) agonism for psychosis: a living systematic review and meta-analysis of human and non-human data [version 1; peer review: 2 approved] [PDF]

Wellcome Open Research
Background Trace amine-associated receptor 1 (TAAR1) agonism shows promise for treating psychosis, prompting us to synthesise data from human and non-human studies.
Fiona J. Ramage, Spyridon Siafis, Edoardo G. Ostinelli, Virginia Chiocchia, Claire Stansfield, Simonne Wright, Ioannis Mantas, Damian Omari Juma, Grazia Rutigliano, Oliver D. Howes, Francesca Tinsdeall, Lea Milligan, Claire Friedrich, Julian H. Elliott, Carmen Moreno, Ava Homiar, James Thomas, Emily S. Sena, Malcolm R. Macleod, Charlotte Austin, Nobuyuki Nomura, Jaycee Kennett, Soraya Seedat, Luke J. Vano, Andrea Cipriani, Olena Maksym, Jennifer Potts, David Gilbert, Thomy Tonia, Robert A. McCutcheon, Matthias Egger, Stefan Leucht, Toshi A. Furukawa, Hossein Dehdarirad, Janna Hastings, Susan Michie, Georgia Salanti, Olufisayo Elugbadebo, Ouma Simple   +38 more
doaj   +5 more sources

Trace amine-associated receptor 1: a multimodal therapeutic target for neuropsychiatric diseases [PDF]

Expert Opinion on Therapeutic Targets, 2018
The trace amines, endogenous amines closely related to the biogenic amine neurotransmitters, have been known to exert physiological and neurological effects for decades. The recent identification of a trace amine-sensitive G protein-coupled receptor, trace amine-associated receptor 1 (TAAR1), and subsequent development of TAAR1-selective small-molecule
Michael D. Schwartz, Juan J. Canales, Riccardo Zucchi, Stefano Espinoza, Ilya Sukhanov, Raul R. Gainetdinov   +5 more
core   +7 more sources

In-vivo pharmacology of Trace-Amine Associated Receptor 1

European Journal of Pharmacology, 2015
Trace-amines (TAs) are endogenous amines that are implicated in several physiological processes including modulation of aminergic neurotransmission. These compounds exert their effect by activating a class of G protein-coupled receptors termed Trace-Amine Associated Receptors (TAARs), where TAAR1 is the only human receptor that has been shown to bind ...
Lam VM, Espinoza S, Gerasimov AS, Gainetdinov RR, Salahpour A   +4 more
openaire   +4 more sources

AlphaFold accelerated discovery of psychotropic agonists targeting the trace amine-associated receptor 1. [PDF]

Sci Adv
Artificial intelligence is revolutionizing protein structure prediction, providing unprecedented opportunities for drug design. To assess the potential impact on ligand discovery, we compared virtual screens using protein structures generated by the AlphaFold machine learning method and traditional homology modeling. More than 16 million compounds were
Díaz-Holguín A, Saarinen M, Vo DD, Sturchio A, Branzell N, Cabeza de Vaca I, Hu H, Mitjavila-Domènech N, Lindqvist A, Baranczewski P, Millan MJ, Yang Y, Carlsson J, Svenningsson P.   +13 more
europepmc   +6 more sources

The trace amine-associated receptor 1 modulates methamphetamine’s neurochemical and behavioural effects [PDF]

Frontiers in Neuroscience, 2015
The newly discovered trace amine-associated receptor 1 (TAAR1) has the ability to regulate both dopamine function and psychostimulant action. Here, we tested in rats the ability of RO5203648, a selective TAAR1 partial agonist, to modulate the ...
Rachel eCotter, Yue ePei, Yue ePei, Liudmila eMus, Anja eHarmeier, Raul eGainetdinov, Marius Christian Hoener, Juan J Canales   +7 more
doaj   +4 more sources

Trace Amine-Associated Receptor 1 Modulates Dopaminergic Activity

The Journal of Pharmacology and Experimental Therapeutics, 2008
The recent identification of the trace amine-associated receptor (TAAR)1 provides an opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor-mediated effects. To separate both effects on a physiological level, a Taar1 knockout mouse line was generated.
Lindemann, Lothar, Meyer, Claas Aiko, Jeanneau, Karine, Bradaia, Amyaouch, Ozmen, Laurence, Bluethmann, Horst, Bettler, Bernhard, Wettstein, Joseph G., Borroni, Edilio, Moreau, Jean-Luc, Hoener, Marius C.   +10 more
openaire   +3 more sources

Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats [PDF]

Frontiers in Psychiatry
IntroductionAggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain.
Ilya S. Zhukov, Ilya S. Zhukov, Yazen Alnefeesi, Natalya A. Krotova, Vsevolod V. Nemets, Konstantin A. Demin, Marina N. Karpenko, Evgeny A. Budygin, Evgeny V. Kanov, Evgeny V. Kanov, Allan V. Kalueff, Allan V. Kalueff, Allan V. Kalueff, Allan V. Kalueff, Petr D. Shabanov, Michael Bader, Natalia Alenina, Raul R. Gainetdinov, Raul R. Gainetdinov   +18 more
doaj   +2 more sources